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Addition/Correction pubs.acs.org/jmc
Cite This: J. Med. Chem. 2017, 60, 9912−9912
Correction to Fragment-Based Identification of Influenza Endonuclease Inhibitors Cy V. Credille, Yao Chen, and Seth M. Cohen* Journal of Medicinal Chemistry 2016, 59, 6444−6454. DOI: 10.1021/acs.jmedchem.6b00628 Page 6445. In Table 1, the IC50, pIC50, and LE values of compound 5 are incorrect. They should be 68 ± 11 nM, 7.2, and 0.89, respectively. The reported values correspond to a different chemical entity; this error was caused by a mislabeling-error in screening of the fragment library. The main text is unaffected by this error. Compound 5 was only discussed as a tolerated structural analogue of compound 1, which remains true despite our error. The corrected Table 1 is shown here. Table 1. Select MBP Fragments That Displayed Potent Inhibition against Influenza PA Endonuclease31,a
pIC50 is defined as pIC50 = −log(IC50) and is included to allow a linear comparison between IC50 values. Ligand efficiency (LE) provides a measure of binding energy per non-hydrogen atom in the fragment molecule. a
Published: December 1, 2017 © 2017 American Chemical Society
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DOI: 10.1021/acs.jmedchem.7b01683 J. Med. Chem. 2017, 60, 9912−9912
