Addition & Correction Cite This: ACS Biomater. Sci. Eng. XXXX, XXX, XXX−XXX
Correction to Latent, Immunosuppressive Nature of Poly(lactic-co-glycolic acid) Microparticles Riley P. Allen, Amir Bolandparvaz, Jeffrey A. Ma, Vishal A. Manickam, and Jamal S. Lewis* ACS Biomater. Sci. Eng. 2018 4(3), 900−918. DOI: 10.1021/acsbiomaterials.7b00831
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he authors have made a minor correction to Figure 3. Figure 3C in the published manuscript is a duplicate of Figure 3B and is not representative of the data presented in the results and discussed elsewhere. The corrected Figure 3 is shown here.
Received: May 8, 2018
© XXXX American Chemical Society
A
DOI: 10.1021/acsbiomaterials.8b00540 ACS Biomater. Sci. Eng. XXXX, XXX, XXX−XXX
ACS Biomaterials Science & Engineering
Addition & Correction
Figure 3. Low-molecular-weight PLGA MPs are immunosuppressive in coculture with DCs. (A) Schematic of the experimental setup used for the maturation and maturation resistance experiments. (B) Dendritic cells were incubated with 2 different formulations of PLGA (50:50, 75:25) and PLA MPs at time points ranging from 6 to 120 h, washed, and then subsequently immuno-stained for MHCII, CD80, and CD86. Immature DCs and LPS treated (1.5 μg/mL) DCs served as controls for nonactivated and activated groups, respectively. The composite maturation indices (unweighted average of the expression of CD80, CD86, and MHCII) of DCs at each time point are shown, normalized to the iDC population. (C) Dendritic cells treated with PLGA MPs, and subsequently challenged with LPS, show resistance to LPS maturation. DCs were incubated with 2 different formulations of PLGA (50:50, 75:25) and PLA at time points ranging from 6 to 120 h, washed, and then subsequently challenged with LPS (1.5 μg/mL) for 24 h. Pair-wise significant differences from the iDC population is denoted by the * symbol (p ≤ 0.05; n = 3 biological replicates).
B
DOI: 10.1021/acsbiomaterials.8b00540 ACS Biomater. Sci. Eng. XXXX, XXX, XXX−XXX
