Addition/Correction pubs.acs.org/jmc
Correction to Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5‑a]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach Tomomi Kosugi, Dale R. Mitchell,* Aiko Fujino, Minoru Imai, Mika Kambe, Shinji Kobayashi, Hiroaki Makino, Yohei Matsueda, Yasuhiro Oue, Kanji Komatsu, Keiichiro Imaizumi, Yuri Sakai, Satoshi Sugiura, Osami Takenouchi, Gen Unoki,* Yuko Yamakoshi, Vicky Cunliffe, Julie Frearson, Richard Gordon, C. John Harris, Heidi Kalloo-Hosein, Joelle Le, Gita Patel, Donald J. Simpson, Brad Sherborne, Peter S. Thomas, Naotaka Suzuki, Midori Takimoto-Kamimura, and Ken-ichiro Kataoka Journal of Medicinal Chemistry 2012, 55, 6700−6715. DOI: 10.1021/jm300411k S Supporting Information *
Page 6713. An updated Supporting Information file associated with this Addition and Correction is available with the following modifications:
Page 6707. The entries 51, 52, and 53 in Table 5 were incorrectly shown with R6 as H rather than methyl. The corrected Table 5 is provided below. Table 5. IC50 values for 7-Position Derivatives
Published: October 25, 2012 © 2012 American Chemical Society
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Journal of Medicinal Chemistry
Addition/Correction
Page S23 of Supporting Information. Compound 46 is now named correctly as the S enantiomer. Page S31 of Supporting Information. Compound 45 is now named correctly as the racemate.
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ASSOCIATED CONTENT
S Supporting Information *
Corrected file (see above) associated with this Addition and Correction that lists experimental details for the synthesis of all compounds and spectral data of all intermediates and final compounds; kinase selectivity panel for (S)-44; THP-1 cell based assay concentration effect curves for (S)-44, 59, and 64. This material is available free of charge via the Internet at http://pubs. acs.org.
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