Addition/Correction Cite This: J. Med. Chem. 2019, 62, 4780−4781
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Correction to Synthesis of 11C‑Labeled RXR Partial Agonist 1‑[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imaging Thereof Osamu Shibahara, Masaki Watanabe, Yuta Takamura, Shoya Yamada, Masaru Akehi, Takanori Sasaki, Akiya Akahoshi, Takahisa Hanada, Hiroyuki Hirano, Shunsuke Nakatani, Hiromi Nishioka, Yasuo Takeuchi, and Hiroki Kakuta* J. Med. Chem. 2017, 60 (16), 7139−7145. DOI: 10.1021/acs.jmedchem.7b00817 Page 7144. Synthetic information for 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-5(trimethylstannyl)1H-benzo[d][1,2,3]triazole (8) should be revised as follows: Hexamethylditin (50 μL, 0.24 mmol) and tetrakis(triphenylphosphine)palladium(0) (10 mg, 0.0087 mmol) were added to a solution of 6 (20 mg, 0.050 mmol) in toluene (3 mL). The reaction mixture was stirred under reflux and held in an Ar atmosphere for 15 min, then filtered through Celite. The solvent was evaporated under reduced pressure, and the residue was purified by flash column chromatography (EtOAc/ n-hexane = 1/40) to yield 8 (16.8 mg, 70%) as a white solid. Page 7144. The author contributions should be modified to indicate persons in charge of PET data analysis as follows: O.S., Y.T., and T.S. analyzed PET data.
We have identified several errors in this article relating to the real-time changes in regions of interest (ROI) in PET images and experimental information, which should be corrected as follows. Page 7139. The author list should be modified to include a new author, Yuta Takamura, affiliated with Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan. The correct author listing is shown above. Page 7141. Figure 2 and its legend in the published paper should be revised as shown below. Page 7142. In the left-hand column, starting from the second line from the bottom, the text should be “brain uptake was the fourth largest, after liver, heart and kidney (Figure 2).” Page 7143. In the right column, in the paragraph entitled “HPLC Conditions for Isolating PET Tracer” the text should be revised as follows: The HPLC system was a CFN-MPS-100 system equipped with an RI detector, consisting of a PU-2086 Plus pump and UV-2075 Plus UV−vis spectrophotometric detector (Sumitomo Heavy Industry, Osaka, Japan). Chromatographic isolation was carried out on a YMC Pack ODS-AM (10 mm i.d. × 250 mm, YMC Co., Ltd., Kyoto, Japan). The recorded data were processed using Chromeleon version 6.50 software. The mobile phase was MeOH/H2O = 90/10 + 0.1% formic acid. The flow rate was 4.0 mL/min, and the absorbance at 260 nm was monitored. Page 7143. In the right column, in the paragraph entitled “HPLC Conditions for Analyzing PET Tracer” the text should be revised as follows: The HPLC system was a Shimadzu liquid chromatographic system (Kyoto, Japan) consisting of a LC-20Ai pump, a SPD20A UV−vis spectrophotometric detector, GABI* (Raytest, Germany), and CTO-20A column oven, with LabSolutions software. The flow rate was 0.7 mL/min on an Intersil ODS-3 column (4.6 mm i.d. × 100 mm, 3 mm, GL Science, Tokyo, Japan) kept at 40 °C; the mobile phase was MeOH/H2O = 85/15 + 0.1% formic acid. Monitoring was done at 260 nm. Identification of the products was confirmed based on the UV spectrum acquired with a PDA detector. © 2019 American Chemical Society
Published: April 19, 2019 4780
DOI: 10.1021/acs.jmedchem.9b00617 J. Med. Chem. 2019, 62, 4780−4781
Journal of Medicinal Chemistry
Addition/Correction
Figure 2. Real-time changes in regions of interest (ROI) in PET images of brain (closed blue triangle), heart (closed pink circle), liver (closed red circle), kidney (closed green diamond), muscle (closed yellow square). Time course of [11C]1 administered iv was obtained from the mean pixel radioactivity in the ROI of the PET images acquired after administration. Data shown are the average (n = 3) ± SD. (A) brain, (B) heart, (C) liver, (D) kidney, and (E) muscle.
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DOI: 10.1021/acs.jmedchem.9b00617 J. Med. Chem. 2019, 62, 4780−4781
