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BIOCHEMISTRY,

VOL.

FREE VIDEO COURSE PREVIEW Your choice: • Chemical Laboratory Techniques • Technical Writing • Organic Chemistry/ Laboratory Techniques • Interpretation of Infrared Spectra • Chemical Engineering for Chemists American Chemical Society Video Courses are complete full-color professional-level programs. They feature prominent chemists a n d other recognized authorities teaching a n d illustrating their courses with clear a n d vivid graphics. Specially edited preview cassettes are available for each of the five video courses listed above for a free three-day examination. You c a n select any title in your choice of 3U" U-matic, 1 /2" VHS, or 1/2" Betamax format. For more Information, use coupon below or call (202) 8724593. American Chemical Society Education Division, Room 810 1155 Sixteenth Street, N.W. Washington, DC 20036 Yes! I want a free preview of a Video Course. Please send catalog and details so I may choose the one that interests me most.

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Biochemistry Biochemistry (ISSN 0006-2960) is published biweekly by the American Chemical Society at 1155 16th Street, N.W., Washington, D.C. 20036. Second-class postage paid at Washington, D.C., and additional mailing offices. POSTMASTER: Send address changes to Biochemistry, Membership and Subscription Services, P.O. Box 3337, Columbus, Ohio 43210. American Chemical Society 1155 16th Street, Ν.W. Washington, D.C. 20036 (202) 872-4600 [TDD (202) 872-8733]

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Biochemistry EDITOR

HANS NEURATH Department of Biochemistry University of Washington Seattle, Washington 98195 (206) 543-1690

ASSOCIATE EDITORS

EARL W. DAVIE

University of Washington EDMOND H. FISCHER

University of Washington MILTON P. GORDON

University of Washington WILLIAM W. PARSON

University of Washington

EDITORIAL ADVISORY BOARD ROBERT H. ABELES

CLAUDE HÉLÈNE

Brandeis University

DEMETRIOS PAPAHADJOPOULOS

University of California, San Francisco

DAVID S. AULD

Museum National d'Histoire Naturelle, Paris

Harvard Medical School

JOHN W. B. HERSHEY

Massachusetts Institute of Technology

ROBERT L. BALDWIN

University of California, Davis

DAVID C. PHILLIPS

Stanford University

PETER C. HINKLE

University of Oxford

STEVEN J. BENKOVIC

Cornell University, Ithaca

JAMES H. PRESTEGARD

The Pennsylvania State University

TONY E. HUGLI

Yale University

GUNTER BLOBEL

Scripps Clinic & Research Foundation

PETER REICHARD

The Rockefeller University

HANS JÖRNVALL

Karolinska Institute, Stockholm

AKSEL A. BOTHNER-BY

Karolinska Institute, Stockholm

JAMES F. RIORDAN

Carnegie-Mellon University

Η. RONALD KABACK

Harvard Medical School

BILL R. BRINKLEY

Roche Institute of Molecular Biology

RANDY W. SCHEKMAN

Baylor College of Medicine

PAUL KAESBERG

University of California, Berkeley

ERNESTO CARAFOLI

University of Wisconsin

HAROLD A. SCHERAGA

ΕΤΗ, Zurich

NEVILLE R. KALLENBACH

Cornell University, Ithaca

MARY LOU PARDUE

MINOR J. COON

University of Pennsylvania

GÜNTHER SCHÜTZ

The University of Michigan

GEORGES KOEHLER

RAYMOND A. DWEK

Basel Institute of Immunology, Basel

German Cancer Research Center, Heidelberg

University of Oxford

JOSEPH KRAUT

EDWARD M. SCOLNICK

WERNER W. FRANKE

University of California at San Diego

Merck Sharp & Dohme

German Cancer Research Center, Heidelberg

ROBERT J. LEFKOWITZ

G. GRAHAM SHIPLEY

Duke University

Boston University

CARL FRIEDEN

HENRY METZGER

ANTERO G. So

Washington University IRVING H. GOLDBERG

NIADDK, National Institutes of Health

CHARLES C. SWEELEY

Harvard Medical School

PAUL L. MODRICH

Michigan State University

RICHARD W. HANSON

Duke University

EDWIN W. TAYLOR

Case Western Reserve University

ELIZABETH NEUFELD

University of Chicago

WILLIAM F. HARRINGTON

University of California, Los Angeles

BERT L. VALLEE

Johns Hopkins University

JAMES OFENGAND

Harvard Medical School

ROBERT HASELKORN

Roche Institute of Molecular Biology

University of Miami

KENSAL E. VAN HOLDE

University of Chicago

Oregon State University

OSAMU HAYAISHI

SALIH J. WAKIL

Osaka Medical College

Baylor College of Medicine