2A
BIOCHEMISTRY,
VOL.
FREE VIDEO COURSE PREVIEW Your choice: • Chemical Laboratory Techniques • Technical Writing • Organic Chemistry/ Laboratory Techniques • Interpretation of Infrared Spectra • Chemical Engineering for Chemists American Chemical Society Video Courses are complete full-color professional-level programs. They feature prominent chemists a n d other recognized authorities teaching a n d illustrating their courses with clear a n d vivid graphics. Specially edited preview cassettes are available for each of the five video courses listed above for a free three-day examination. You c a n select any title in your choice of 3U" U-matic, 1 /2" VHS, or 1/2" Betamax format. For more Information, use coupon below or call (202) 8724593. American Chemical Society Education Division, Room 810 1155 Sixteenth Street, N.W. Washington, DC 20036 Yes! I want a free preview of a Video Course. Please send catalog and details so I may choose the one that interests me most.
25,
NO.
11,
Biochemistry Biochemistry (ISSN 0006-2960) is published biweekly by the American Chemical Society at 1155 16th Street, N.W., Washington, D.C. 20036. Second-class postage paid at Washington, D.C., and additional mailing offices. POSTMASTER: Send address changes to Biochemistry, Membership and Subscription Services, P.O. Box 3337, Columbus, Ohio 43210. American Chemical Society 1155 16th Street, Ν.W. Washington, D.C. 20036 (202) 872-4600 [TDD (202) 872-8733]
Organization Address City, State, Zip This offer expires August 31,1986 and is available in the U.S. only.
Books and Journals Division D. H. Michael Bowen, Director JOURNALS
Membership and Subscription Services American Chemical Society P.O. Box 3337, Columbus, Ohio 43210 (614) 421-3776 Journals Department American Chemical Society 2540 Olentangy River Road P.O. Box 3330, Columbus, Ohio 43210 (614) 421-3600, ext 3171 (TELEX 6842086) © Copyright 1986 by the American Chem ical Society. Copyright permission: An indi vidual may make a single reprographic copy of an article in this publication for personal use. Reprographic copying beyond that permitted by Section 107 or 108 of the U.S. Copyright Law is allowed, provided that the appropriate per-copy fee is paid through the Copyright Clearance Center, Inc., 27 Congress St., Salem, Massachusetts 01970. For reprint permission, please write to the Copyright Administrator, Books and Journals Division, at the ACS Washington address. Editorial Information Instructions to authors and copyright status form are printed in the first issue of each vol ume. Please conform to these instructions when submitting manuscripts. Manuscripts for publication should be sub mitted to the Editor, Hans Neurath, Depart ment of Biochemistry, University of Washing ton, Seattle, Washington 98195. Correspond ence regarding accepted papers and proofs should be directed to the Journals Department at the address above. Page charges of $30.00 per page may be paid for papers published in this journal. Payment does not affect accept ance or scheduling of papers. Bulk reprints of individual articles are available. For informa tion write to Distribution Office at the ACS Washington address. The American Chemical Society and its Ed itors assume no responsibility for the statements and opinions advanced by contributors. Registered names and trademarks, etc., used in this publication, even without specific indi cation thereof, are not to be considered unpro tected by law. Subscription and Business Information 1986 subscription prices including postage.
Name Title
1986
U.S. Printed Members Nonmembcrs Microfiche Members Nonmembers Supplementary material on microfiche
All Other Canada Europe Countries and Air Service Air Service Mexico Included Included
S 65 $334
$98 $367
$130 $399
$155 $424
S 65 $334
$65 $334
$89 $358
$ 89 $358
$30
$40
$40
$40
Charles R. Bertsch, Head; Marianne C. Brogan, Associate Head; Mary E. Scanlan, Assistant Manager; Deborah K. Miller, Supervisory Editor; Beth A. Rogers, Ruth A. Linville, and Darrell McGeorge, Assistant Editors; Barbara I. Taylor, Staff Editor PRODUCTION
Elmer M. Pusey, Jr., Head RESEARCH AND DEVELOPMENT
Lorrin R. Garson, Head Advertising Office: Centcom, Ltd., 25 Sylvan Road South, Westport, CT 06881. Subscriptions are available only on a calendar year basis. (For membership information, con tact Office of Membership Development at the ACS Washington address.) New and renewal subscriptions should be sent with payment to Business Management Division, ACS, P.O. Box 57136, West End Station, Washington, D.C. 20037. Rates do not apply to nonmember subscribers in Japan, who must enter subscription orders with Maruzen Company Ltd., 3-10 Nihonbashi 2chome, Chuo-ku, Tokyo 103, Japan. Tel: (03) 272-7211. Printed edition single issue prices: current year $14.00; prior year $16.00. Back volume price: $403.00. Foreign postage additional. Mail orders should be sent to Microforms & Back Issues Office at the ACS Washington address. Phone orders can be placed for print ed, microfiche, and microfilm editions by call ing the ACS Sales Office TOLL FREE at (800) 424-6747 from anywhere in the conti nental United States; Washington, D.C, area call (202) 872-8065. Phone orders can be charged to Visa, MasterCard, or American Express accounts. Changes of address must include both old and new addresses with ZIP code and a recent mailing label. Send all address changes to Membership and Subscription Services. Please allow 6 weeks for change to become effective. Claims for missing numbers will not be allowed if loss was due to failure of notice of change of address to be received in the time specified; if claim is dated (a) North America, more than 90 days beyond issue date; (b) all other foreign, more than one year beyond issue date; or if the reason given is "missing from files". Hard copy claims are handled by Membership and Sub scription Services. Supplementary material is noted in the table of contents with a • . It is available as photo copy ($6.00 for up to 3 pages and $1.50 per page for additional pages, plus $2.00 for foreign postage) or as 24X microfiche ($6.00, plus $1.00 for foreign postage). See supplementary material notice at end of journal article for number of pages. Orders must state whether for photocopy or microfiche and give complete title of article, names of authors, journal, issue date, and page numbers. Prepayment is re quired and prices are subject to change. Order from Microforms & Back Issues Office at the ACS Washington address. Supplementary material also appears in the microfilm edition and may be ordered by subscription (in micro fiche only). Cover: Based on apohemoglobin β subunit—courtesy of Jane S. Richardson.
Biochemistry EDITOR
HANS NEURATH Department of Biochemistry University of Washington Seattle, Washington 98195 (206) 543-1690
ASSOCIATE EDITORS
EARL W. DAVIE
University of Washington EDMOND H. FISCHER
University of Washington MILTON P. GORDON
University of Washington WILLIAM W. PARSON
University of Washington
EDITORIAL ADVISORY BOARD ROBERT H. ABELES
CLAUDE HÉLÈNE
Brandeis University
DEMETRIOS PAPAHADJOPOULOS
University of California, San Francisco
DAVID S. AULD
Museum National d'Histoire Naturelle, Paris
Harvard Medical School
JOHN W. B. HERSHEY
Massachusetts Institute of Technology
ROBERT L. BALDWIN
University of California, Davis
DAVID C. PHILLIPS
Stanford University
PETER C. HINKLE
University of Oxford
STEVEN J. BENKOVIC
Cornell University, Ithaca
JAMES H. PRESTEGARD
The Pennsylvania State University
TONY E. HUGLI
Yale University
GUNTER BLOBEL
Scripps Clinic & Research Foundation
PETER REICHARD
The Rockefeller University
HANS JÖRNVALL
Karolinska Institute, Stockholm
AKSEL A. BOTHNER-BY
Karolinska Institute, Stockholm
JAMES F. RIORDAN
Carnegie-Mellon University
Η. RONALD KABACK
Harvard Medical School
BILL R. BRINKLEY
Roche Institute of Molecular Biology
RANDY W. SCHEKMAN
Baylor College of Medicine
PAUL KAESBERG
University of California, Berkeley
ERNESTO CARAFOLI
University of Wisconsin
HAROLD A. SCHERAGA
ΕΤΗ, Zurich
NEVILLE R. KALLENBACH
Cornell University, Ithaca
MARY LOU PARDUE
MINOR J. COON
University of Pennsylvania
GÜNTHER SCHÜTZ
The University of Michigan
GEORGES KOEHLER
RAYMOND A. DWEK
Basel Institute of Immunology, Basel
German Cancer Research Center, Heidelberg
University of Oxford
JOSEPH KRAUT
EDWARD M. SCOLNICK
WERNER W. FRANKE
University of California at San Diego
Merck Sharp & Dohme
German Cancer Research Center, Heidelberg
ROBERT J. LEFKOWITZ
G. GRAHAM SHIPLEY
Duke University
Boston University
CARL FRIEDEN
HENRY METZGER
ANTERO G. So
Washington University IRVING H. GOLDBERG
NIADDK, National Institutes of Health
CHARLES C. SWEELEY
Harvard Medical School
PAUL L. MODRICH
Michigan State University
RICHARD W. HANSON
Duke University
EDWIN W. TAYLOR
Case Western Reserve University
ELIZABETH NEUFELD
University of Chicago
WILLIAM F. HARRINGTON
University of California, Los Angeles
BERT L. VALLEE
Johns Hopkins University
JAMES OFENGAND
Harvard Medical School
ROBERT HASELKORN
Roche Institute of Molecular Biology
University of Miami
KENSAL E. VAN HOLDE
University of Chicago
Oregon State University
OSAMU HAYAISHI
SALIH J. WAKIL
Osaka Medical College
Baylor College of Medicine