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Curcumin Induces Apoptosis of Colorectal Cancer Stem Cells by Coupling with CD44 Marker Yu-Ting Huang, Yu-Wei Lin, Han-Mo Chiu, and Been-Huang Chiang J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.5b05649 • Publication Date (Web): 24 Feb 2016 Downloaded from http://pubs.acs.org on February 27, 2016
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Journal of Agricultural and Food Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
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Journal of Agricultural and Food Chemistry
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Curcumin Induces Apoptosis of Colorectal Cancer Stem Cells by
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Coupling with CD44 Marker
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Yu-Ting Huang†, Yu-Wei Lin†, Han-Mo Chiu‡, Been-Huang Chiang†*
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† Institute of Food Science and Technology, College of Bio-resources and Agriculture, National Taiwan University, Taipei 10617, Taiwan ‡ Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 10051, Taiwan Running title:
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Curcumin induced apoptosis in CCSC
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*Please send all correspondence to:
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Dr. Been Huang Chiang
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Institute of Food Science and Technology,
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National Taiwan University
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No.1, Section 4, Roosevelt Road, Taipei 10617, Taiwan
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Tel. no. (886)-2- 3366-4119
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E-mail:
[email protected] 18 1
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Journal of Agricultural and Food Chemistry
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Keywords: colorectal cancer; cancer stem cells; colorectal cancer stem cells;
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curcumin; apoptosis; CD44
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Abbreviations:
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CRC, Colorectal cancer; CSCs, Cancer stem cells; CCSC, Colorectal cancer
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stem cells; 5FU, 5-Fluorouracil; MMP-9, metalloproteinase-9; PK, pyruvate
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kinase; CUR, curcumin
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Journal of Agricultural and Food Chemistry
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ABSTRACT
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This study investigated the effect of curcumin on colorectal cancer stem
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cells (CCSCs) and its possible mechanism. Comparison of the metabolic
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profiles of human adenomatous polyp (N=61) and colorectal cancer (CRC)
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(N=57) tissue found statistically significant differences (p
