Current Fluoroorganic Chemistry - American Chemical Society

withdrawing properties of the perfluoroalkyl ponytails have a decreasing effect ... minimize the electron-withdrawing effect of the fluorous ponytails...
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Chapter 11

Fluorous Nanoflow Microreactor: Nanoflow Microreactor with Fluorous Lanthanide Catalysts for Increase in Reactivity and Selectivity Downloaded by UNIV OF LIVERPOOL on December 14, 2015 | http://pubs.acs.org Publication Date: January 11, 2007 | doi: 10.1021/bk-2007-0949.ch011

Koichi Mikami and Takayuki Tonoi Department of Applied Chemistry, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8552, Japan

The regioselectivity and reaction rate of the fluorous lanthanide complex-catalyzed Mukaiyama aldol and BaeyerVilliger reactions were significantly increased using our nanoflow microreactor. A moderate level of kinetic resolution was also observed even in the lowest concentration of the fluorous lanthanide catalysts (catalyst-to-substrate (C/S) molar ratio is less than 1:1000(