Curry Compound Shows Promise As Drug - C&EN Global Enterprise

Apr 26, 2004 - T here's more good news about curry. According to a new report, curcumin—an anticancer compound (C&EN, Sept. 1,2003, page 8) that is ...
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CHEMICALS

KKRSNAPSUP CHEMICAL UNITS Investment firm's buy of four businesses will create large specialties player

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Kohlberg Kravis Roberts & Co., majority owner of Rockwood Specialties Group, is backing Rockwood's acquisition of four Dynamit Nobel chemical businesses forroughly $2.7billion. KKR won out over competing bids from a variety of private in­ vestors and chemical companies. The Dynamit Nobel business­ es, which are now owned by M G Technologies, had sales last year of $1.8 billion. The amalgamated total will be more than triple Rockwood's current annual sales of some $800 million. The four units are CeramTec, which makes advanced ceramics; Chemetall, producer of surface treatment and lithium chemicals; Sachtleben Chemie, manufac­ turer of titanium dioxide, func­ tional additives, and water treat­ ment products; and the DNES Custom Synthesis business. ForMGlechnologies, the deal is a giant step toward exiting the chemical industry according to Chairman Udo G. Stark. It still has two units to shed: plastics for the automotive industry and chemicals distributor Solvadis. M G agreed to the deal with Rockwood, Stark says, because "the combination of Dynamit Nobel and Rockwood will create aglobal leader in specialty chem­ icals and advanced materials." Rockwood itself was created in 2000, when KKR bought a set of businesses from Laporte, pri­ or to that company's acquisition by Degussa. Rockwood focuses on specialty chemicals for pig­ ments, wood surface treatment, water treatment, clay electron­ ics, and advanced materials. It HTTP://WWW.CEN-ONLINE.ORG

currently operates 40 facilities in North America, Europe, and Asia with a workforce of 2,500. Rockwood CEO Seifi Ghasemi says that with the Dynamit Nobel businesses, "we will create a strong, profitable, and global specialty chemicals and advanced materials company" Reaching a critical mass in spe­ cialty chemicals is agoal ofthe deal, agrees Todd Fisher, partner and managing director at KKR. "We have been highly supportive of Rockwood to date and look for­ ward to supporting the combined company to become aworldleader in quality and innovation in the chemical industry" Fisher says. T h e purchase continues a spate of chemical acquisitions by private investors, who see an op­ portunity in companies that the stock market doesn't value high­ ly. Blackstone Group just won

MEDICINAL

shareholder approval for its $3.8 billion purchase of Celanese. And chemical companies bought last year by private investors include Ondeo Nalco, SigmaKalon, and Kraton Polymers. K K R already owns Borden Chemical, the Columbus, Ohiobased adhesives resins maker. KKR's effort to build Rockwood into a sizeable specialties player is reminiscent of the work by Scan­ dinavian venture capital fund Industri Kapital, which cobbled to­ gether Finnish specialty chemicals company Dynea. However, the fund's subsequent efforts to create a Nordic specialties giant through a merger of Dynea with Kemira were unsuccessful.—PATRICIA

ULTRAPURE Dynamit Nobel specializes in pro­ duction of advanced ceramic materials.

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CHEMISTRY

Curry Compound Shows Promise As Drug here's more good news about curry. er reaches the cell surface to perform its usual According to a new report, curcufunction. min—an anticancer compound Yale professor Michael J. Caplan and col­ (C&EN, Sept. 1,2003, page 8) that is leagues found that when they feed cur­ a major constituent of the spice C H Q cumin to mice with the AF508 mutation, turmeric—may offer promise for the misfolded protein appears to evade treating cystic fibrosis. excision and goes on to perform its n o r m a l function in the cells that line In the study, researchers at Yale Univer­ the rodent's nose and rectum. Capsity School of Medicine and the University of lan's group cautions that their suc­ Toronto found that in mice, curcumin can cor cess in treating mice does not guaran­ rect a defect that commonly causes cystic fi­ tee that curcumin w i l l be effective in brosis [Science, 304, 600 (2004)]. That humans. The group is optimistic, how­ defect, a mutation in the gene ever, because studies have shown that AF508, results in a misfolded pro- CH30 people can consume large amounts of tein. The misfolded protein gets curcumin without apparent toxicity.— removed by the cell's "quality conHO BETHANY HALFORD t r o l " mechanisms and therefore nevCurcumin

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