ARTICLE
CuS Nanodots with Ultrahigh Efficient Renal Clearance for Positron Emission Tomography Imaging and Image-Guided Photothermal Therapy Min Zhou,† Junjie Li,† Su Liang,† Anil K. Sood,‡,§ Dong Liang,^ and Chun Li*,†,§ †
Department of Cancer Systems Imaging, ‡Departments of Gynecologic Oncology & Reproductive Medicine and Cancer Biology, and §Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States and ^Department of Pharmaceutical Sciences, Texas Southern University, Houston, Texas 77004, United States
ABSTRACT Translation of nanoparticles (NPs) into clinical practice has been limited by toxic effects
induced by nonspecific accumulation of NPs in healthy organs after systemic administration. The ideal NPs should accumulate in the target site, carry out their function, and then ultimately be eliminated from the body. Here, we show a single-compartment, multifunctional ultrasmall copper sulfide nanodot (CuS ND) that is rapidly cleared from the body. These CuS NDs have a hydrodynamic diameter of
