Design and chemical synthesis of a sequence-specific DNA-cleaving

David P. Mack, Brent L. Iverson, and Peter B. Dervan. J. Am. Chem. .... Marisol Rodriguez , Thomas Kodadek , Maritza Torres , and Allen J. Bard. Bioco...
4 downloads 0 Views 957KB Size
J . Am. Chem. SOC.1988, 110, 7572-7574

7572

0.8

'.0.2 O

4

/ //

r

Figure 2. Absorption spectra of photopolymerized multibilayer film of 1 at 22 "C ( l ) , at 50 O C (2), and after cooling back to 22 "C.

temperature in a thermostated cup-horn sonicator. Differential scanning calorimetry (Microcal MC-2) of membranes of 1 indicates the T, is 14.6 "C. Hydrated bilayer membranes of 1 were not photosensitive unless they were cooled below room temperature with an ice bath. As noted previously lipid diacetylene bilayers are photopolymerizable only in the solid analogous phase (