Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase

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Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa Cheng Ji, Indrajeet Sharma, Debarshi Pratihar, L. Lynn Hudson, Damien Maura, Tezcan Guney, Laurence G. Rahme, Everett C. Pesci, James P. Coleman, and Derek S. Tan* ACS Chem. Biol. 2016, 11 (11), 3061−3067, DOI: 10.1021/acschembio.6b00575. uring the preparation of this manuscript, Figure 2 was inadvertently altered such that the values listed on the y

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Figure 2. Inhibition of HHQ (8 h) and PQS (20 h) quinolone production in P. aeruginosa strain PA14 (1.5 mM inhibitors). Statistical significance relative to the blank was assessed using a two-tailed unpaired Student t-test with 95% confidence intervals; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.

axes were 10-fold lower than intended. The corrected version of Figure 2 is provided. This correction does not alter the conclusions of the paper. We apologize for any confusion resulting from this error.

© XXXX American Chemical Society

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DOI: 10.1021/acschembio.9b00298 ACS Chem. Biol. XXXX, XXX, XXX−XXX