ORGANIC LETTERS
Diastereoselective Dearomatization of Resorcinols Directed by a Lactic Acid Tether: Unprecedented Enantioselective Access to p-Quinols
2004 Vol. 6, No. 10 1535-1538
Lupe H. Mejorado, Christophe Hoarau, and Thomas R. R. Pettus* Department of Chemistry and Biochemistry, UniVersity of California at Santa Barbara, Santa Barbara, California 93106-9150
[email protected] Received January 24, 2004
ABSTRACT
An operationally simple oxidative dearomatization of resorcinol derivatives is reported that employs an inexpensive chiral directing group. The method provides access to a variety of p-quinol derivatives in good yield and diastereoselectivity. A short reductive process affords 4-hydroxy-4-alkylcyclohexenone derivatives in excellent yields and enantiomeric excesses.
Four types of chiral cyclohexadienones have proven extremely useful in natural product synthesis (see Figure 1, A-D).1 Despite their usefulness, there are relatively few ways to prepare or use A-D in an enantioselective format. Fujioka and co-workers prepared and examined the reactivity of a chiral ketal derived from the masked o-benzoquinone A and observed it to undergo diastereoselective reductions.2 o-Quinol building blocks of the general structure B have been examined by a number of groups. Methods for their preparation include the oxidatively triggered ipso cyclization of an oxime reported by Hoshino3 and the bacterial oxidations of phenols described separately by Myers4 and Breitmaier.5 With regard to masked p-benzoquinones C, Corey,6 Wipf,7 (1) Magdziak, D.; Meek, S.; Pettus, T. R. R. Chem. ReV. 2004, 104, 1383-1429. (2) Fujioka, H.; Annoura, H.; Murano, K.; Kita, Y.; Tamura, Y. Chem Pharm Bull. 1989, 37, 2047-2052. (3) Murakata, M.; Yamada, K.; Hoshino, O. J. Chem. Soc., Chem. Commun. 1994, 443-444. (4) Myers, A. G.; Siegel, D. R.; Buzzard, D. J.; Charest, M. G. Org. Lett. 2001, 3, 2923-2926. (5) Kneifel, H.; Poszich-Buscher, C.; Rittich, S.; Breitmaier, E. Angew. Chem., Int. Ed. Engl. 1991, 30, 202-203. (6) Corey, E. J.; Wu, L. I. J. Am. Chem. Soc. 1993, 115, 9327-9328. 10.1021/ol0498592 CCC: $27.50 Published on Web 04/16/2004
© 2004 American Chemical Society
Figure 1. Some useful chiral cyclohexadienones.
and Porco8 have independently investigated epoxidations of chiral ketal derivatives. Taylor, on the other hand, has (7) Wipf, P.; Kim, Y.; Jahn, H. Synthesis 1995, 1549-1561. (8) Hu, Y.; Li, C.; Kulkarni, B. A.; Strobel, G.; Lobkovsky, E.; Torczynski, R. M.; Porco, J. A., Jr. Org. Lett. 2001, 3, 1649-1652.
championed the asymmetric Julia-Colonna epoxidation of these systems,9 while Feringa has studied asymmetric 1,4additions of diethylzinc.10 Other asymmetric strategies developed by de March,11 Winterfeldt,12 Carreno,13 Wipf,14 and Corey15 utilize enantioselective desymmetrization of various prochiral MPB ketals with an asymmetric DielsAlder cycloaddition followed by subsequent diastereoselective reactions and a retro-cycloaddition. With regard to p-quinol systems such as D, a similar masking strategy has been employed. Winterfeldt demonstrated that these systems engage in diastereoselective [4 + 2] cycloadditions with an unusual chiral diene,16 while Feringa has reported that symmetric derivatives of D undergo asymmetric 1,4-additions with diethylzinc in the presence of a chiral ligand.17 Despite these many successes, a careful examination of the literature suggests that improvements could be made particularly with regard to the range of derivatives that are prepared by current enantioselective technologies. Recently, we described a novel oxidative dearomatization for the conversion of 4-alkylated resorcinol derivatives into a lactone intertwined with a p-quinol. We also showed that this p-quinol scaffold is capable of undergoing a variety of diastereoselective reactions, which include 1,2-additions, 1,4conjugate additions, and [4 + 2] cycloadditions (Scheme 1).18
Following a methodical investigation, we are now able to report that the cyclohexadienone scaffolds of type 14-18 can be obtained with excellent enantioselectivity and in respectable yield (Table 1). To the best of our knowledge,
Table 1. Diastereoselective Dearomatization of Resorcinol Derivatives
Scheme 1. Diastereoselective Reactions of p-Quinols (R ) -Et)a
a Key: (a) PhMgBr; (b) KHMDS/H C(CO Me) ; (c) Danishef2 2 2 sky’s diene; (d) MeOH/NBS then Zn; (e) Rh(PPh3)3Cl/H2 for 10 h; (f) Rh(PPh3)3Cl/H2 for 2 h.
Furthermore, we demonstrated the usefulness of this intermediate in efficient albeit racemic syntheses of epoxysorbicillinol and bisorbicillinol.18b (9) Genski, T.; Macdonald, G.; Wei, X.; Lewis, N.; Taylor, R. J. K. Synlett 1999, 795-797. (10) Imbos, R.; Minnaard, A. J.; Feringa, B. L. Tetrahedron 2001, 57, 2485-2489. (11) de March, P.; Escoda, M.; Figueredo, M.; Font, J.; Garcia-Garcia, E.; Rodriguez, S. Tetrahedron: Asymmetry 2000, 11, 4473-4483. (12) Wolter, M.; Borm, C.; Merten, E.; Wartchow, R.; Winterfeldt, E. Eur. J. Org. Chem. 2001, 4051-4060. (13) Carreno, M. C.; Gonzalez, M. P.; Fisher, J. Tetrahedron Lett. 1995, 36, 4893-4896. (14) Wipf, P.; Jung, J.-K. J. Org. Chem. 2000, 65, 6319-6337. (15) Breuning, M.; Corey, E. J. Org. Lett. 2001, 3, 1559-1562. 1536
this diastereoselective dearomatization of resorcinol derivatives is unique. However, it requires access to 4-alkyl (16) Gerstenberger, I.; Hansen, M.; Mauvais, A.; Wartchow, R.; Winterfeldt, E. Eur. J. Org. Chem. 1998, 643, 3-650. Org. Lett., Vol. 6, No. 10, 2004
monoprotected resorcinols, which we prepare using oquinone methide chemistry developed in our group.19 Our synthesis of these substrates begins with bromination20 of the aldehyde 1 and subsequent bis-BOC protection, which affords the bromo aldehyde 2 in greater than 70% yield (Scheme 2). Reduction of the aldehyde 2 with NaBH4
Hydrogenation of p-quinol (+)-14 over rhodium (Rh/Al, 150 psi H2, THF) chemoselectively reduces the enone functionality and affords the vinylogous ester (+)-20 in 70% yield (Scheme 3). Subsequent hydrogenolysis of the bromine
Scheme 3. Scheme 2.
Cleavage of Directing Group
Preparation of Resorcinol Precursors
provides the corresponding benzyl alcohol, which upon treatment with an excess of a nucleophile generates an o-quinone methide. A conjugate addition ensues and provides the monoprotected 4-alkylated resorcinol derivatives 3-7 in good yields (59-89%). These phenols undergo Mitsunobu coupling with 2S-hydroxy-N-methoxy-N-methylpropionamide (-)-821 and thereby afford phenols (9-13) upon deprotection with ZnBr2 (4 equiv, 0.1 M in CH3NO2) in >75% yield over the three steps. As shown in Table 1, exposure of these readily prepared chiral resorcinols (9-13) to 1.1 equiv of PhI(OCOCF3)2 (0.3 h, 0.1 M CH2Cl2:CH3NO2/1:2.5, 0 °C) followed by an aqueous workup affords a series of chiral lactone scaffolds (14-18) in good yields with excellent diastereoselectivity. Because the protocol proves diastereoselective with a variety of differently sized C4-substituents, the magnitude of asymmetric induction afforded by the chiral amide appears independent of the steric bulk of the C-4 substituent. (17) Imbos, R.; Brilman, M. H. G.; Pineschi, M.; Feringa, B. L. Org. Lett. 1999, 1, 623-625. (18) (a) Van De Water, R. W.; Hoarau, C.; Pettus, T. R. R. Tetrahedron Lett. 2003, 44, 5109-5113. (b) Pettus, L. H.; Van De Water, R. W.; Pettus, T. R. R. Org. Lett. 2001, 3, 905-908. (19) (a) Van De Water, R. W.; Magdziak, D. J.; Chau, J. N.; Pettus, T. R. R. J. Am. Chem. Soc. 2000, 122, 6502-6503. (b) Jones, R.; Van De Water, R. W.; Lindsey, C.; Hoarau, C.; Ung; T.; Pettus, T. R. R. J. Org. Chem. 2001, 66, 3435-3441. (c) Hoarau, C.; Pettus, T. R. R. Synlett 2003, 127. (d) Tuttle, K.; Pettus, T. R. R. Synlett 2003, 2234-2236. (e) Lindsey, C.; Gomez-Diaz, C.; Villalba, J. M.; Pettus, T. R. R. Tetrahedron 2002, 58, 4559-4565. (20) Bui, E.; Bayle, J. P.; Perez, F.; Liebert, L.; Courtieu, J. Liquid Crystals 1990, 8, 513-526. (21) (a) Paterson, I.; Wallace, D. J.; Cowden, C. J. Synthesis 1998, 639652. (b) Less, S. L.; Leadlay, P. F.; Dutton, C. J.; Staunton, J. Tetrahedron Lett. 1996, 37, 3519-3520. Org. Lett., Vol. 6, No. 10, 2004
atom and hydrogenation of the vinylogous ester in (+)-20 is accomplished with Pd/C (1 atm, 1.0 equiv of Hu¨nig’s base, 0.1 M EtOAc) and affords the lactone (+)-19 in quantitative yield. The relative stereochemistry of the protons (Ha-Hd) in (+)-19 was established by 2D-NOESY experiment. In our experience, a two-step reduction protocol is preferred to a single-pot reduction of (+)-13 with PtO2 (4 h, 1 atm H2) because the yields of the latter procedure prove quite variable (40-80%) and afford significant quantities of rearomatized materials. Addition of solid KOTMS to (+)-19 (1.1 equiv, 0.1 M Et2O, rt) affords the enantiomerically enriched ketone (+)-21 in >95% yield. Comparison with a racemic standard by chiral GC analysis demonstrated that (+)-20 is obtained in >99% ee by this eight-pot process. It should be noted that β-elimination, which is necessary for formation of the enone (+)-21, most likely does not occur until the lactone undergoes ring opening and a subsequent ring-flip. With regard to the diastereoselectivity of this process, it appears that the major isomer arises from the boat transition state B, while the chair transition state A leads to the minor diastereomer (Figure 2). The boat transition state is not objectionable because most sites in the forming and neighboring six-membered ring are sp2 hybridized. The Weinreb amide affords much higher diastereoselectivity than other amides. Presumably, there is less steric interaction between the -OMe and -Br in the Weinreb amide than the corresponding interaction between an alkyl and -Br substituent in other amides in the transition state. The >25% improvement in yields and reproducibility in this dearomatization process as compared with earlier des-bromo desmethyl examples18a can be attributed to a favorable steric interaction that facilitates lactonization, as well as prevention of undesired aryl couplings with the oxidant.18a,22 It appears that a C2 substituent, such as bromine, limits the degrees of (22) Murakata, M.; Yamada, K.; Hoshino, O. J. Chem. Soc., Chem. Commun. 1994, 443-445. 1537
This method provides a flexible chiral scaffold, which subsequently allows access to a variety of p-quinols and their derivatives in good yield and enantioselectivity. On the basis of our previous observations with related systems,18 easy access to a great many types of chiral ensembles can be imagined. We expect this enantioselective dearomatization process may prove useful in syntheses of nonracemic molecules. Acknowledgment. Research Grants from the National Science Foundation (Career-0135031) and National Institutes of Health (GM-64831) are greatly appreciated. L.H.M. gratefully acknowledges additional financial support provided by J. H. Tokuyama and a minority supplement (GM-64831) for furthering his research. We also thank the patient editors of the American Chemical Society, who strive to do an outstanding job. Figure 2. Boatlike transition state is preferred.18b
freedom and assists in placing the amide carbonyl in closer proximity to the intended site of reaction.
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Supporting Information Available: Experimental procedures and full spectral data for compounds 2-21. This material is provided free of charge via the Internet at http://pubs.acs.org OL0498592
Org. Lett., Vol. 6, No. 10, 2004
