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Bioactive Constituents, Metabolites, and Functions
Dietary Wheat Bran Oil is equally effective as Rice Bran Oil in Reducing Plasma Cholesterol Lin Lei, Jingnan Chen, Yuwei Liu, Lijun Wang, Guohua Zhao, and Zhen-Yu Chen J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.7b06093 • Publication Date (Web): 04 Mar 2018 Downloaded from http://pubs.acs.org on March 6, 2018
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Journal of Agricultural and Food Chemistry
Dietary Wheat Bran Oil is equally effective as Rice Bran Oil in Reducing Plasma Cholesterol
Lin Lei,†,‡ Jingnan Chen,# Yuwei Liu,£ Lijun Wang,€ Guohua Zhao,† Zhen-Yu Chen‡,*
†
‡
#
College of Food Science, Southwest University, Chongqing 400715, China
School of Life Sciences, The Chinese University of Hong Kong, Hong, Kong, China
Provincal Key Laboratory for Transformation and Utilization of Cereal Resource, Henan University of Technology, Zhengzhou, Henan, China £
School of Public Health, Fudan University, Shanghai, China €
Shenzhen Institute for Drug Control, Shenzhen, China
_____________________________________________________________________________________________________
* Corresponding author: Room 179, Science Centre South Block, The Chinese University
of
Hong
Kong,
Shatin,
NT,
Hong
Kong,
China.
[email protected]; Tel : (852) 3943-6382; fax :(852) 2603-7246. ‡
L. Lei and J. Chen contribute equally to this work.
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Journal of Agricultural and Food Chemistry
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ABSTRACT: Rice bran oil (RBO) possesses a plasma-cholesterol lowering activity, while
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effect of wheat bran oil (WBO) on plasma cholesterol remains unknown. The present
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study compared the cholesterol-lowering activity of WBO with that of RBO in hamsters.
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Fifty-four male hamsters were divided into seven groups fed either a non-cholesterol
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diet (NCD) or one of six high-cholesterol diets namely, HCD diet (0.2% cholesterol +
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9.5% lard), HCD+C diet (0.2% cholesterol + 9.5% lard + 0.5% cholestyramine), WL diet
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(0.2% cholesterol + 4.8% Lard + 4.8% WBO), WH diet (0.2% cholesterol + 9.5% RBO), RL
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diet (0.2% cholesterol + 4.8% Lard + 4.8% RBO), and RH diet (0.2% cholesterol + 9.5%
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RBO). Plasma total cholesterol (TC) in HCD group was 327.4 ±31.8 mg/dL, while plasma
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TC in two WBO and two RBO groups was 242.2±20.8, 243.1±31.7, 257.1±16.3 and
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243.4±46.0 mg/dL, respectively, leading to a decrease in plasma TC by 22-26% (P
