BIOCHEMISTRY
Dilatometric Study of the Interactions of Bovine Serum Albumin with Urea* Sam Katzt and T. G. Ferris
ABSTRACT: This dilatometric study of the interaction of bovine serum albumin with urea relates the resultant volume changes to the conformational changes produced by the denaturation process. The volume changes were determined with a modified Teflon-sheathed Linderstr@m-Lang-Lanz [Linderstrgm-Lang, K., and Lam, H. (1938), Compt. Rend. Trao Lab. Carlsberg 24, I] type dilatometer. The experimental precision of 7 M urea were invariant after mixing, whereas at lower urea concentrations there was a slight decrease in volume with time,
