Direct, Label-Free, and Rapid Transistor-Based Immunodetection in

Aug 30, 2017 - To the best of our knowledge, this is the first demonstration of direct immunodetection in whole serum using transistor-based biosensor...
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Article pubs.acs.org/acssensors

Direct, Label-Free, and Rapid Transistor-Based Immunodetection in Whole Serum Ó scar Gutiérrez-Sanz,† Nesha M. Andoy,† Marcin S. Filipiak,†,‡ Natalie Haustein,†,§ and Alexey Tarasov*,†,‡ †

BioMed X Innovation Center, 69120 Heidelberg, Germany Institute for Physical Chemistry, Universität Heidelberg, 69120 Heidelberg, Germany § Institute for Materials Science, Technische Universität Dresden, 01062 Dresden, Germany ‡

S Supporting Information *

ABSTRACT: Transistor-based biosensors fulfill many requirements posed upon transducers for future point-of-care diagnostic devices such as scalable fabrication and label-free and real-time quantification of chemical and biological species with high sensitivity. However, the short Debye screening length in physiological samples (