Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5

Apr 21, 2017 - We have discovered a novel series of tetrahydrobenzimidazoles 3 as TGR5 agonists. Initial structure–activity relationship studies wit...
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Letter

Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type II Diabetes Xuqing Zhang, Mark Wall, Zhihua Sui, Jack Kauffman, Cuifen Hou, Cailin Chen, Fuyong Du, Thomas Kirchner, Yin Liang, Dana L. Johnson, William V Murray, and Keith Demarest ACS Med. Chem. Lett., Just Accepted Manuscript • Publication Date (Web): 21 Apr 2017 Downloaded from http://pubs.acs.org on April 22, 2017

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ACS Medicinal Chemistry Letters is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.

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