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Food and Beverage Chemistry/Biochemistry
Consumption of 1-5 whole eggs dose-dependently increases liver cholesterol but not plasma cholesterol and egg white has no effect on liver and plasma cholesterol in hamsters Hanyue Zhu, Zouyan He, Erika Kwek, Jianhui Liu, Wangjun Hao, Ning Liang, Yimin Zhao, Ka Ying Ma, Wen-Sen He, and Zhen-Yu Chen J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.8b04730 • Publication Date (Web): 10 Nov 2018 Downloaded from http://pubs.acs.org on November 21, 2018
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Journal of Agricultural and Food Chemistry
Consumption of 1-5 whole eggs dose-dependently increases liver cholesterol but not plasma cholesterol and egg white has no effect on liver and plasma cholesterol in hamsters
Hanyue Zhu ‡, Zouyan He ‡, Erika Kwek ‡, Jianhui Liu ‡, Wangjun Hao ‡, Ning Liang ‡,
‡
Yimin Zhao ‡, Ka Ying Ma ‡, Wen-Sen He ‡,†,, Zhen-Yu Chen ‡*
School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
†
School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, Jiangsu, China
*Email:
[email protected]; telephone: (852) 3943-6382; fax: (852) 2603-7246.
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Journal of Agricultural and Food Chemistry
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Abstract
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It remains inconclusive regarding the dose-dependent effect of egg
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consumption on plasma cholesterol in humans. It is unknown if egg white consumed
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in a normal amount can reduce plasma cholesterol. We used hamsters as a model to
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(i) investigate the dose-dependent effect of consuming 0 to 5 whole eggs on plasma
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total cholesterol (TC), and (ii) examine if egg white equivalent to 1-5 eggs possessed
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any reducing effect on plasma TC. In experiment 1, hamsters were divided into 6
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groups (n=8 each) and fed either a control diet or five experimental diets
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supplemented with whole egg powders equivalent to 1 to 5 eggs/2000 kcal. Results
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showed that supplementation of one egg increased plasma TC by 25% compared
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with the control (226±16 versus 282±56 mg/dL, p
