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3'-Hydroxypterostilbene Suppresses Colitis-Associated Tumorigenesis by Inhibition of IL-6/ STAT3 Signaling in Mice Ching-Shu Lai, Guliangyang Yang, Shiming Li, Pei-Sheng Lee, Bini Wang, MinChing Chung, Kalyanam Nagabhushanam, Min-Hsiung Pan, and Chi-Tang Ho J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.7b03712 • Publication Date (Web): 16 Oct 2017 Downloaded from http://pubs.acs.org on October 17, 2017
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Journal of Agricultural and Food Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.
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Journal of Agricultural and Food Chemistry
3'-Hydroxypterostilbene
IL-6
JAK P
P
AOM/DSS
P P P STAT3 STAT3
STAT3
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Colitis-associated CRC Inflammatory gene STAT3
STAT3
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SOCS3↓
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3'-Hydroxypterostilbene suppresses AOM/DSS induced colon tumorigenesis by inhibition IL-6/ ACS Paragon Plus Environment STAT3 signaling
Journal of Agricultural and Food Chemistry
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3'-Hydroxypterostilbene Suppresses Colitis-Associated Tumorigenesis by Inhibition of IL-6/ STAT3 Signaling in Mice
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Ching-Shu Lai#, Guliang Yang$, Shiming Li$, Pei-Sheng Lee&, Bi-Ni Wang§,
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Min-Ching Chung#, Nagabhushanam KalyanamΠ, Chi-Tang Hoψ, Min-Hsiung
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Pan$,&,€,∆,*
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#
Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung
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811, Taiwan
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$
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Comprehensive Utilization; Hubei Collaborative Innovation Center for the
Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources
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Characteristic Resources Exploitation of Dabie Mountains; Huanggang Normal
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University, Huanggang, Hubei, China
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&
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Taiwan
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§
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University, Xi’an 710119, China
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Π
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ψ
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Taiwan
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€
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University, Taichung 40402,
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∆
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Taiwan
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*Please send all correspondence to:
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Dr. Min-Hsiung Pan
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Institute of Food Science and Technology,
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National Taiwan University
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No.1, Section 4, Roosevelt Road, Taipei 10617, Taiwan
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E-mail:
[email protected] 29
Tel. no. +886-2-33664133
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Fax no. +886-2-33661771
Institute of Food Science and Technology, National Taiwan University, Taipei 10617,
College of Food Engineering and Nutritional Science, Shaanxi Normal
Sabinsa Corporation, East Windsor, New Jersey, United States of America
Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA
Department of Medical Research, China Medical University Hospital, China Medical
Department of Health and Nutrition Biotechnology, Asia University, Taichung,
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1
ACS Paragon Plus Environment
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Journal of Agricultural and Food Chemistry
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ABSTRACT
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3'-Hydroxypterostilbene (trans-3,5-dimethoxy-3',4'-hydroxystilbene) presents in
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Sphaerophysa salsula, Pterocarpus marsupium, and Honey Bee propolis and has been
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reported to exhibit several biological activities. Herein, we aimed to explore the
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chemopreventive effects of dietary 3'-hydroxypterostilbene and underlying molecular
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mechanisms on colitis-associated cancer using the azoxymethane (AOM)/dextran
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sodium sulfate (DSS) model. 3'-Hydroxypterostilbene administration effectively
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ameliorated the colon shortening and number of tumors in AOM/DSS-treated mice
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(3.2 ± 1.2 of the high dose treatment versus 13.8 ± 5.3 of the AOM/DSS group,
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p
