A New Synthesis of Acetyl Dihydrogen Phosphate1 - Journal of the

Ronald Bentley. J. Am. Chem. Soc. , 1948, 70 (6), ... Ronald Bentley. Journal of Chemical Education 2001 78 (2), ... Bruce Gaede. Organic Process Rese...
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A NEWSYNTHESIS OF ACETYL DIHYDROGEN PHOSPHATE

June, 1948 [CONTRIBUTION FROM

THE

2183

DEPARTMENT OF BIOCHEMISTRY, COLLEGE OF PHYSICIANS AND SURGEONS, COLUMBIA UNIVERSITY]

A New Synthesis of Acetyl Dihydrogen Phosphate1 BY RONALD BENTLEY~ Acetyl dihydrogen phosphate (I) was first syn- lide. Analogous reactions were observed with thesized by Lynen3 who used the catalytic de- ammonia. benzylation of acetyl diRNHZ in RNHi>pcO Heat in RNHs>pGO benzyl phosphate. Later, ___) Lipmann and ‘I’uttle‘ de- H>pc>COCHs ether RNH, O-COCH, EtOH RNHI H scribed its preparation I1 CH,COOQHb from silver dihydrogen aq. R N H ~ J phosphate and acetyl chloride; in each case the aceRNH3>P