Sept'ember 1968
1103
New Compounds Adaniantylamines by Direct Amination of 1-Bromoadamantane
TABLEI1
E i m s V. KRUMICALKS A N D W i L L I . u r PFEIFER
Eli Lilly and Companij, Greenfield Labomtories, Greenjeld, Indiana
46140
Received .Ilairh 25, 1968
n
3
111 the coitt'he of oiir i,esearch, it became necessary to syiithesize a nitmber of silkistitilted adamantylamiries for otir testiitg p r q p m . As w n e of the derivatives involved diadamantylsiibstit uted amineu, we began to investigate a direct high-temperature niicleophilic siibutitution of bromoadamantanes with the desired amine moiety. The iiriusual reactivity of l-bromoadarnantarie is illtistrated by the iise of heterocyclic amines, such as pyridiiie or imquinolitie, as the reaction media.
Experimental Section M'here attalyres at'e iitdicated oiilg b j mbols of the eleriierits analytical resrilts obtained for those elements or fttiictions wei'e within +0.45 of the theoretical values. JIeltiiig poirtts were taken in an opeii capillary tribe and are uncorrected. N,N-Diadamantylamine Hydrobromide (General Method).In a high-pressiire, stainless steel bomb were charged 10.6 g (0.07 mole) of 1-aniinoadamantane and 10.7 g (0.049 mole) of I-bt,omoadamantane. The bomb was closed and heated overnight at 2.i.i". The container was then cooled to room temperature and the solidified prodiict was removed. The crude reaction mixtiire was dissolved in about 200 nil of hot absolute EtOH, treated with decoloriziiig carboil, and filtered. The desired product, S,N-diadamaritylamiiie hydrobromide, precipitated on cooling. Recrvstallizatioii from EtOH vielded 12.3 g (67.2';), mp 3:Go. d n 2 . ( c ~ ~ H , , N . H BC,~ )H, S Other adamantylamities prepared by this aiid subsequent procediires at'e listed iii Tables I arid 11. 01' fitrictioiis,
Mp,
oc
Yield,
7%
290-291 30 .i 303 3J 7 283-283 20 .)J -10 323 N : calcd, 6.74; foulid, 7.11.
Formula
.inall ses
C,jH,,?;,.2HC1 ClaH4J42.2HC1
C, H ; Na C, H, N C, H, S C, H, X
C27HasNz.2HCl C,,H,zSz.2HC1
layer was made basic and the diamine was e x h c t e d (Et20). The ether layer was washed (H,O) until neutral, dried (sa,sO,), arid concentrated in oacuo. The product was then converted to the dihydrochloride, which, after recrystallization from EtOHEtlO, gave 6 g (46.6%) of product, mp 225-227' (Table 11). Anal. (C141~4~sl.211cl) C, H, S .
Acknowledgments.-The authors are grateful for the advice and guidance of Dr. Jack Jlills in the execlition uf this work. The aiithors also wihh to thank 111.. 13. E. Boaz and M r . D. 0. IT'oolf for physicochemical data and 11r. IT.L. Brown and his associates for niimeroiis microanalyses. The sitstaining interest and advice of Dr. K. Gerzon is worthy of special mention.
Potential Antidiabetics. I. 1-(2,4-Dinitrophenyl)-3,5-dimethyl4-arylazopyrazoles €1. G. G ~ R C ; J N D PREM P i~ SINGH,
TABLE1
Department of Cheniistrlj, Zniz"si1
rj
sf Roorkee, Koorkee, India
Received February 14, 1968
Yield,
R .imino
320 y- H y d r o x ) proli>-Iaininv 9Y-Y,5 N-hl etliylanilino 109-Ill m-Tvlaidino 5 7 . 5-5!) p-Toluidino 66-67 m-Xylidinv 140-141 Piperidino 312-314 4-hIethylp~-ridiniu1n 240-212 dec 'I
%
Formula
.'Lnalyaes
23 11-20 33
CioHiiN.IiCI CiaHrsKo Cj7HnN C~;H~JS CiiHnN CIRHJ~K CijH?,Y.tiCl ClaHinl3rS
C, H, S C, H , N C, H , K C, H ; N" C. H ; N b C, H , N C , €1, S C, €1, N
NlJ, "C
S : cdcd, 5.80; foiuid, 3.27.
-18.8 41 40-45 51
21
N: ralcd, 3.80; found, 6.38.
2-( 1 -Adamantyl )isoquinolinium Bromide.-1-Bi omoadamanlane (.jg, 0.023 mole) and 30 g (0.23 mole) of isoquinoline were heated in an oil bath a t 220' for 16 hr. The flask wa5 cooled and the d u t i o n was concentrated zn uuczm. The solid residue was washed with 230 ml of dry ether. Recrystallization from EtOHEt20 gave 5.4 g (68.3%) of aroduct, mD 272-273". Anal. I
3,.i-l)imethylpyra~[)lewas found to be 30 timer as potent as tolbutamide in lowering blood sugar in glucose-primed, fasted, intact rats.' Our interest i n drugs having hypoglycemic activity led us to prepare a series of compounds containing either a pyrazole or a11 isoxazole ring.,-: This report includes the synthesis of 1-(2,4-diiiitropheiiyl)-3,3-dimethyl-4-ar~lazopyrazoles.
Experimental Section6 2,3,4-Pentanetrione 3-arylhydrazones ere prepared by c-oupling diazotized anilines with 2,4-pentanedione7 by the method of Garg and Joshi,* the compound< 50 obtained are summarized in Table I. Pyrazole Derivatives.-2,lr>iIiitrophenylhy~razine (0.01 mole) dissolved in concentrated H2SO4 (6 ml) and EtOH (50 ml) \\as added to the 2,3,+pentanetrione %phenylhydrazone (0.01 mole) in AcOH and refluxed for 1-3 hr. On cooling shiny crystals
-
( c ~ ~ H ~ ~C,BH,~ Y. K) N,N'-Bis( 1-adamantv1)butanediamineDihvdroch1oride.-In a high-pressiit;e, stainless-steel bomb were charged 13 g (0.069 mole) of 1-hromoadamantane and 2.64 g (0.030 mole) of 1,4-butanediamine. The bomb was then heated at 200' for 16 hr and cooled, and its contents wei'e added to .if;;IICI. Extraction with ether remuved tinreacted adaniantyl bromide. The aqueous acid
( 1 ) G . C. Gerritsen a n d W. E. Dulin, Diabetes, 14, 507 (1965). ( 2 ) H . G . Garg and S. S. Joshi, J . O w . C k e m . , 26, 946 (1961). (3) H. G. Garg, ibid., 46, 948 (1961). (4) H. G. Garg, J . Iridian C h e m . Sac., 39, 563 (1962). ( 5 ) H. G. Garg, ibid., 40, 135 (1963). (6) hlelting points were taken on a KuHer liot stage apparatus. ( 7 ) A produet of British Drup House Ltd. ( 8 ) l i . G. G a r s and S. d. Joshi, J . I d i a n C h e m . Soc., 31, 626 (1960).
