Chem. Res. Toxicol., Vol. 7, No. 4, 1994 583
Additions and Corrections
Additions and Corrections N-Nitroso-N-methylvinylamine: Reaction of the Epoxide with Guanyl and Adenyl Moieties To Yield Adducts Derived from Both Parts of the Molecule [Volume 6, Number 2, MarchIApril 1993, pp 168-1731 OSAMTJ O w ,MAGNUSPERSMARK,AND F. PETER GUENGERICH*
Page 169. In paragraph 1, lines 8 and 9, “1H NMR (‘HCCl3) 6 3.17 (a, 1H, CH3), 4.75 (dd, 1H, CHyCH), 4.85 (apparent dd, 2 H, CH2=CH)” should be changed to the following: “1H NMR (2HCCl3) 6 3.17 (s,3 H, CH3), 4.83 (dd, 1 H, HCH,,=CH, ‘J 1Hz, 3Jcb= 9.3 Hz), 5.08 (dd, 1 H, HCHtra,=CH, ‘J 1 Hz, 3Jtrons = 16 Hz), 7.89 (9,1 H, CHFCH, 3Jc, = 9.4 Hz, 3Jtrans = 9.4 Hz)”. We thank ProfessorR. Loeppky (Universityof Missouri,Columbia,MO) for calling our attention to the original assignment and suggesting reevaluation.
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N
Endogenous DNA Adducts: Potential and Paradox [Volume 6, Number 6, NovembedDecember 1993, pp 771J. hhRNETT* AND PHILIP c. BURCHAM 7851 LAWRENCE Page 779. Table I is missing footnotes g through 1. They are as follows: g F.-L. Chung, personal communication. h J. Swenberg, personal communication. Polycyclic aromatic hydrocarbon-DNA adducts. j From ref 235. 8-(4-Aminobiphenylyl)-2’-deoxyguanosine. 1 Calculated from estimates (26).
Announcements Designing Safer Chemicals The United States Environmental Protection Agency (EPA) and the Division of Environmental Chemistry of the American Chemical Society (ACS) are hosting a one-day symposium entitled “Designing Safer Chemicals” on Thursday, August 25,1994, in Washington, DC. The symposium will be part of the ACS National Meeting to be held in Washington, DC, August 21-25, 1994. The purpose of this symposium is: (1)to stimulate chemical companies to think about the toxicity of chemicals before they are made, and to minimize toxicity whenever possible through rational chemical design; (2) to stimulate academicians to consider research in safe chemical design; and (3) to stimulate funding institutions to consider funding academic research in safe chemical design. Topics that will be covered include: toxic mechanisms; controlling bioactivation; retrometabolic concepts; isoteric replacement; controlling bioavailability; examples of functional groups or chemicals that the EPA is particularly concerned with; and specific examples of how safer chemicals have been designed by commercial manufacturers.
For further information, please contact either: Dr. Stephen C. DeVito (mail code 7406; phone: 202-260-1748; fax: 202-260-0981) or Dr. Roger L. Garrett (mail code 7403; phone: 202-260-4302), U.S.EPA, 401 M Street, S.W., Washington, DC 20460.
0893-228~/94/2707-0583$04.50/0 0 1994 American Chemical Society
584 Chem. Res. Toxicol., Vol. 7, No. 4, 1994
International Society for Free Radical Research 7th Biennial Scientific Meeting The 7th Biennial Scientific Meeting of the International Society for Free Radical Research will be held November 6-10,1994, at the Sydney Convention Centre in Sydney, Australia. The scientific program will consist of plenary and subplenary lectures, workshops, free communication sessions, and poster presentations. Plenary lectures will focus on cardiovascular diseases, cancer, aging, arthritis, gene regulation, antioxidants, vitamins, nutrition, neurology, radical chemistry, exercise physiology, environmental science, food preservation, inflammation, and life-style optimization. Some of the topics to be covered in lectures, workshops, free communication sessions, and poster presentations include chemistry of radical reactions, biochemistry, physiology, and pathology. For further information, please contact: Margaret Blackwell, ISFRR ’94 Secretariat, Box 77 PO, Pymble, NSW 2073, Australia (Phone: 61 2 983 9330; FAX: 61 2 983 9307).
Society for Free Radical Research Satellite Meeting: “Cellular Oxidants: Production and Consequences” A Satellite Meeting of the 7th Biennial Meeting of the International Society for Free Radical Research will be held November 1-3, 1994, in Queenstown, New Zealand. The meeting “Cellular Oxidants: Production and Consequences” will focus on the formation of reactive oxygen species by cells, and the consequences of oxidant production. Morning and evening sessions (afternoons will be free for recreation) will be held on the following topics: Measurement of oxidants produced by cells; Cytokines and redox regulation of gene expression; Mechanisms of radical cytotoxicity; Oxidant involvement in clinical disorders; Oxidant damage to specific targets; Peroxidases; Nitric oxide; Antioxidant defense; Neutrophil oxidants; and Metabolism of xenobiotics. There will be invited speakers on selected topics as well as oral and poster presentations. The best presenter will receive a free “BUNGY JUMP”. For further information, please contact: Cellular Oxidants: Production and Consequences, Postgraduate Health Conferences, Christchurch School of Medicine, PO Box 4345, Christchurch, New Zealand (FAX: 64 3 364 0451; Phone: 64 3 364 0410).
International ISSX Workshop on Glutathione STransferases The International Society for the Study of Xenobiotics (ISSX) is sponsoring an international workshop on “Glutathione S-Transferases” to be held April 22-25,1995, in the Leeuwenhorst Congress Center in Noordwijkerhout, The Netherlands. The objective of this Workshop is to bring together both senior and young scientists to present and discuss the latest developments in the various areas of this important enzyme system. In addition to poster presentations, scientific sessions will cover: (1) Enzymology, structure, and function of glutathione S-transferases (GSTs); (2) Control and regulation of GST expression; (3) GSH/conjugation in vivo; (4) Clinical relevance of GSTs; and (5) GSH, GSTs, electrophiles, and cancer. The attendance to this workshop will be limited. For further information, please contact: Professor Dr. N. P. E. Vermeulen, LACDR-Department of Pharmacochemistry, Free University, De Boelelaan 1083,1081 HV Amsterdam, The Netherlands [Phone: (31) 20 548 2963; Fax: (31) 20 646 14791. Please use the following telephone and fax numbers after July 2, 1994: Phone: (31) 20 444 7590; Fax: (31) 20 444 7610.
Meeting Calendar August 3-5,1994
Thirteenth Summer Symposium in Molecular Biology: “Molecular and Cellular Mechanisms of Toxicity” [Chem. Res. Toxicol. 7 (3), 470,19943.
September 21-24, 1994
Sixth Congress on Nephrotoxicity and Nephrocarcinogenicity [Chem.Res. Toxicol. 7 (21, 275, 19941.
September 25-30, 1994
International Symposium on Human Health and Environment: “Mechanisms of Toxicity and Biomarkers To Assess Adverse Effects of Chemicals” [Chem. Res. Toxicol. 7 (11, 119, 19941.
October 23-27, 1994
Sixth North American ISSX Meeting [Chem. Res. Toxicol. 7 (2), 275, 19943.
January 44,1995
The Fifth International Symposium on Biological Reactive Intermediates [Chem. Res. Toxicol. 7 (2), 276, 19941.
