J. Med. Chem. 2004, 47, 1149-1152
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Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa1 George R. Pettit,*,† Jun-Ping Xu,† Jean-Charles Chapuis,† Robin K. Pettit,† Larry P. Tackett,† Dennis L. Doubek,† John N. A. Hooper,‡ and Jean M. Schmidt† Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 872404, Tempe, Arizona 85287-2404, and Sessile Marine Invertebrates, Queensland Museum, South Brisbane, Queensland 4101, Australia Received April 29, 2003
The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 from 0.001 to
