Assessment and Management of Chemical Risks - ACS Publications

Assessment and Management of Chemical Risks. Joseph V. ... Robert G. Tardiff—Use of toxicity test data in the estimation of risks to human ... Donal...
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Assessment and Management of Chemical Risks Joseph V. Rodricks, EDITOR Downloaded by 80.82.77.83 on January 4, 2018 | http://pubs.acs.org Publication Date: January 13, 1984 | doi: 10.1021/bk-1984-0239.fw001

Environ Corporation

Robert G. Tardiff, EDITOR Life Systems, Inc.

Based on a symposium sponsored by the Division of Chemical Health and Safety at the 184th Meeting of the American Chemical Society, Kansas City, Missouri, September 12-17, 1982

American Chemical Society, Washington, D.C. 1984

Rodricks and Tardiff; Assessment and Management of Chemical Risks ACS Symposium Series; American Chemical Society: Washington, DC, 1984.

Library of Congress Cataloging in Publication Data

Downloaded by 80.82.77.83 on January 4, 2018 | http://pubs.acs.org Publication Date: January 13, 1984 | doi: 10.1021/bk-1984-0239.fw001

Assessment and management of chemical risks. (ACS symposium series, ISSN 0097-6156; 239) Bibliography: p. Includes indexes. Contents: Conceptual basis for risk assessment/ Joseph V. Rodricks and Robert G. Tardiff—Use of toxicity test data in the estimation of risks to human health/Norton Nelson—Interspecies extrapolation/ Daniel B. Menzel and Elaine D. Smolko—[etc.] 1.Toxicity testing—Congresses. 2. Toxicology— Congresses. I. Rodricks, Joseph V. 1938. II. Tardiff, Robert G. III. American Chemical Society. Division of Chemical Health and Safety. IV. American Chemical Society. Meeting (184th: 1982: Kansas City, Mo.) V. Series. RA1199.A77 1984 363.1'79 83-25851 ISBN 0-8412-0821-2

Copyright © 1984 American Chemical Society All Rights Reserved. The appearance of the code at the bottom of the first page of each chapter in this volume indicates the copyright owner's consent that reprographic copies of the chapter may be made for personal or internal use or for the personal or internal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per copy fee through the Copyright Clearance Center, Inc. for copying beyond that permitted by Sections 107 or 108 of the U.S. Copyright Law. This consent does not extend to copying or transmission by any means—graphic or electronic—for any other purpose, such as for general distribution, for advertising or promotional purposes, for creating a new collective work, for resale, or for information storage and retrieval systems. The copying fee for each chapter is indicated in the code at the bottom of the first page of the chapter. The citation of trade names and/or names of manufacturers in this publication is not to be construed as an endorsement or as approval by ACS of the commercial products or services referenced herein; nor should the mere reference herein to any drawing, specification, chemical process, or other data be regarded as a license or as a conveyance of any right or permission, to the holder, reader, or any other person or corporation, to manufacture, reproduce, use, or sell any patented invention or copyrighted work that may in any way be related thereto. Registered names, trademarks, etc., used in this publication, even without specific indication thereof, are not to be considered unprotected by law. PRINTED IN THE UNITED STATES OF AMERICA

Rodricks and Tardiff; Assessment and Management of Chemical Risks ACS Symposium Series; American Chemical Society: Washington, DC, 1984.

ACS Symposium Series M . Joan Comstock, Series Editor

Downloaded by 80.82.77.83 on January 4, 2018 | http://pubs.acs.org Publication Date: January 13, 1984 | doi: 10.1021/bk-1984-0239.fw001

Advisory Board Robert Baker

Geoffrey D. Parfitt

U.S. Geological Survey

Carnegie-Mellon University

Martin L. Gorbaty

Theodore Provder

Exxon Research and Engineering Co.

Glidden Coatings and Resins

Herbert D. Kaesz

James C. Randall

University of California—Los Angeles

Phillips Petroleum Company

Rudolph J. Marcus

Charles N. Satterfield

Office of Naval Research

Massachusetts Institute of Technology

Marvin Margoshes

Dennis Schuetzle

Technicon Instruments Corporation

Ford Motor Company Research Laboratory

Donald E. Moreland U S D A , Agricultural Research Service

Davis L. Temple, Jr. Mead Johnson

W. H. Norton J. T. Baker Chemical Company

Charles S. Tuesday General Motors Research Laboratory

Robert Ory U S D A , Southern Regional Research Center

C. Grant Willson IBM Research Department

Rodricks and Tardiff; Assessment and Management of Chemical Risks ACS Symposium Series; American Chemical Society: Washington, DC, 1984.

Downloaded by 80.82.77.83 on January 4, 2018 | http://pubs.acs.org Publication Date: January 13, 1984 | doi: 10.1021/bk-1984-0239.fw001

FOREWORD T h e A C S S Y M P O S I U M S E R I E S was f o u n d e d i n 1974 to p r o v i d e a m e d i u m for p u b l i s h i n g symposia q u i c k l y i n book f o r m . T h e format of the Series parallels that of the c o n t i n u i n g A D V A N C E S I N C H E M I S T R Y S E R I E S except that i n order to save t i m e the papers are not typeset b u t are r e p r o d u c e d as they are subm i t t e d b y the authors i n camera-ready f o r m . Papers are rev i e w e d u n d e r the supervision of the E d i t o r s w i t h the assistance of the Series A d v i s o r y B o a r d a n d are selected to m a i n t a i n the integrity of the symposia; however, v e r b a t i m reproductions of p r e v i o u s l y p u b l i s h e d papers are not accepted. B o t h reviews a n d reports of research are acceptable since symposia m a y embrace b o t h types of presentation.

Rodricks and Tardiff; Assessment and Management of Chemical Risks ACS Symposium Series; American Chemical Society: Washington, DC, 1984.