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Bioactive Constituents, Metabolites, and Functions
Bacterial cellulose relieves diphenoxylate-induced constipation in rats Xichuan Zhai, Dehui Lin, Yan Zhao, and Xingbin Yang J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.8b00385 • Publication Date (Web): 07 Apr 2018 Downloaded from http://pubs.acs.org on April 10, 2018
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Journal of Agricultural and Food Chemistry
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Journal of Agricultural and Food Chemistry
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Bacterial cellulose relieves diphenoxylate-induced constipation in rats
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Xichuan Zhaia, Dehui Lina*, Yan Zhaob, Xingbin Yanga*
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a
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Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China
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b
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Northwest of China, College of Life Science, Shaanxi Normal University, Xi'an 710062, China
Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, College of Food
National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in
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Corresponding authors
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E-mail address:
[email protected];
[email protected] 10
Tel.: +86-29-85310580; Fax: +86-29-85310517
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Conflict of Interest: The authors declare no competing financial interest.
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Journal of Agricultural and Food Chemistry
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ABSTRACT
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This study was to probe the effects of bacterial cellulose (BC) on diphenoxylate-induced
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constipation in rats. Administration with BC at 500 mg/kg·bw in diphenoxylate-induced
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constipation rats distinctly improved the carmine propulsion rate (83.5 ± 5.2%), shortened the
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defecating time of the first red feces (249.0 ± 23.3 min), and increased the weight of carmine red
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feces within 5 h (2.7 ± 1.3 g). The levels of aquaporins (AQP-2, AQP-3 and AQP-4) and
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inhibitory neurotransmitters (nitric oxide, nitric oxide synthetase, vasoactive intestinal peptide
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and arginine vasopressin) in the BC-treated groups reduced by 31.9-40.0% (p
