BBB b − ≡

-15

U-U

b 2

*

-10

pentamer

tetramer

trimer

dimer

-5

N-N

0

Ci

HS B B − b2* ≡ 22 HS 22 B22

i

ε+/- or εhp

ε+/-

TM

U D

⎛ ∆Gi0 ⎞ = exp ⎜ − ⎟ ⎝ k BT ⎠

λ σ0

σ0

( Cmon )

W2

Ki ≡

weakly hydrophobic

Young and Roberts, J. Chem. Phys. (2007, in press)

-20

-15

-12

-9

-6

-3

0

strongly hydrophobic

Cell-based theory provides accurate statistical thermodynamics of dilute solutions & basis for multi-scale simulations of dense fluids. Example below is for the free energy of cluster formation in colloid or protein solutions (φ < ca. 2%)