Article pubs.acs.org/ac
Bovine Serum Albumin-Based Probe Carrier Platform for Electrochemical DNA Biosensing Yin-Huan Liu,†,‡,∥ Hong-Na Li,†,‡,∥ Wei Chen,*,†,‡ Ai-Lin Liu,†,‡ Xin-Hua Lin,*,†,‡ and Yuan-Zhong Chen*,§ †
Department of Pharmaceutical Analysis and ‡Nano Biomedical Technology Research Center, Fujian Medical University, Fuzhou 350004, China § Fujian Institute of Hematology, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, China S Supporting Information *
ABSTRACT: A bovine serum albumin (BSA)-monolayer-based probe carrier platform is shown to improve the performance of a conventional thiolated single-stranded DNA probe self-assembledmonolayer-based electrochemical DNA hybridization biosensor. A detection limit of 0.5 fM can be obtained in a very reproducible manner (relative standard deviation
