Enantiospecific Hydroxylation of Alkanes Catalyzed by Transitional Metal Complexes of Chiral TPA Zhaohua Dai Pace University • •
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R1
Chiral-TPA Fe(II) Complexes
R1
*
CH2 R2
CH H2O2
R2
OH
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To Convert saturated C-H bonds directly into chiral alcohols Made chiral ligands and used their Fe-(II) complexes as catalysts Systematically rigidified the chiral ligand to improve enantio- and regio- selectivity Put Br on ligands to increase reactivity according DFT calculation Catalysis works Enantioselectivity to be investigated
