Chemical Reviews special thematic issue
Combinatorial Chemistry
This special thematic issue of Chemical Reviews offers a sampling of current efforts in this exciting field. Reflecting the diversity of efforts that is contained within combinatorial chemistry, the reviewers' viewpoints run from the strictly synthetic to almost purely biochemical. Topic Covered •
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Ojborne and tlllncton locus Vn ttie selection 01 bi1ding moms srom random libraries, including efforts to increase diversity and manipulate the proptrtiCJ 01 tne JClected enLitieJ tnrougn tne use ol Iucleotide analogs. Dreaxtr explores tne catalytic dbllities of nucleic acids and tne use 01 increasingly sophisticated selections to derive catajysts for an ever wider range ot cnemicai trdJs\ormations. Petrenko and Smith provide a comprehensive survey of the peptide motiIJ tnat nave been l^flaled or denned by pMage disp/ay 01 pepLides and proteins and offer some interesting comments on strategies for the exploration of sequence space. Lam, Lebl, and Krehnak review the one-bead-one-compound approach with coverage of synthetic methods, screening technologies, approaches to decoding theses pools, and an array of specific examples of compounds isolated in th1s manner. Nefzi, Ostresh, and Houghten ucscribe the remarkable range u i classCJ ot cnemicai compounds tor wlIcn llbraries nave been svntnesized b^ solid-phase methods. Pirrung focuses on spatially addressable synthetic approaches to solid-phase synthesis. Gravert and janda survey recent progress in a hybrid approach to library synthesis—the use of soluble polymeric supports in ettorts to combine the advantages of traditional liouid/phase synthesis with the benefits of solid-phase synthesis.
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Analytical Chemistry News & Features, October 1, 1997
