Conformationally Directed Drug Design - ACS Publications

Carnegie-Mellon University. Theodore Provder. Glidden Coatings and Resins ... Ford Motor Company. Research Laboratory. Davis L. Temple, Jr. Mead Johns...
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Downloaded by 80.82.77.83 on May 21, 2018 | https://pubs.acs.org Publication Date: April 24, 1984 | doi: 10.1021/bk-1984-0251.fw001

Conformationally Directed Drug Design

Vida and Gordon; Conformationally Directed Drug Design ACS Symposium Series; American Chemical Society: Washington, DC, 1984.

Vida and Gordon; Conformationally Directed Drug Design ACS Symposium Series; American Chemical Society: Washington, DC, 1984.

Downloaded by 80.82.77.83 on May 21, 2018 | https://pubs.acs.org Publication Date: April 24, 1984 | doi: 10.1021/bk-1984-0251.fw001

ACS

SYMPOSIUM

SERIES

Conformationally Directed Drug Design

Downloaded by 80.82.77.83 on May 21, 2018 | https://pubs.acs.org Publication Date: April 24, 1984 | doi: 10.1021/bk-1984-0251.fw001

Peptides and Nucleic Acids as Templates or Targets Julius A. Vida, E D I T O R Bristol-Myers Company Maxwell Gordon, E D I T O R Bristol-Myers Company

Based on a symposium sponsored by the Division of Medicinal Chemistry at the 186th Meeting of the American Chemical Society, Washington, D.C., August 28-September 2, 1983

American Chemical Society, Washington, D.C. 1984

Vida and Gordon; Conformationally Directed Drug Design ACS Symposium Series; American Chemical Society: Washington, DC, 1984.

251

Library of Congress Cataloging in Publication Data Conformationally directed drug design. (ACS symposium series, ISSN 0097-6156; 251) Includes bibliographies and indexes.

Downloaded by 80.82.77.83 on May 21, 2018 | https://pubs.acs.org Publication Date: April 24, 1984 | doi: 10.1021/bk-1984-0251.fw001

1. Chemistry, Pharmaceutical—Congresses. 2. Peptides—Congresses. 3. Nucleic acids—Congresses. 4. Structure-activity relationship (Pharmacology)— Congresses. 5. Stereochemistry—Congresses. I. Vida, Julius Α., 1928. II. Gordon, Maxwell, 1921. III. American Chemical Society. Division of Medicinal Chemistry. IV. American Chemical Society. Meeting (186th: 1983: Washington, D.C.) V. Series. [ D N L M : 1. Nucleic acid conformation—Congresses. 2. Protein conformation—Congresses. 3. Chemistry, Pharmaceutical—Congresses. Q U 58 C7487 1983] RS401.C66 1984 ISBN 0-8412-0836-0

615'.31

84-2921

Copyright © 1984 American Chemical Society All Rights Reserved. The appearance of the code at the bottom of the first page of each chapter in this volume indicates the copyright owner's consent that reprographic copies of the chapter may be made for personal or internal use or for the personal or internal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per copy fee through the Copyright Clearance Center, Inc., 21 Congress Street, Salem, M A 01970, for copying beyond that permitted by Sections 107 or 108 of the U.S. Copyright Law. This consent does not extend to copying or transmission by any means—graphic or electronic—for any other purpose, such as for general distribution, for advertising or promotional purposes, for creating a new collective work, for resale, or for information storage and retrieval systems. The copying fee for each chapter is indicated in the code at the bottom of the first page of the chapter. The citation of trade names and/or names of manufacturers in this publication is not to be construed as an endorsement or as approval by ACS of the commercial products or services referenced herein; nor should the mere reference herein to any drawing, specification, chemical process, or other data be regarded as a license or as a conveyance of any right or permission, to the holder, reader, or any other person or corporation, to manufacture, reproduce, use, or sell any patented invention or copyrighted work that may in any way be related thereto. Registered names, trademarks, etc., used in this publication, even without specific indication thereof, are not to be considered unprotected by law. P R I N T E D IN T H E U N I T E D STATES O F

AMERICA

Vida and Gordon; Conformationally Directed Drug Design ACS Symposium Series; American Chemical Society: Washington, DC, 1984.

A C S Symposium Series

Downloaded by 80.82.77.83 on May 21, 2018 | https://pubs.acs.org Publication Date: April 24, 1984 | doi: 10.1021/bk-1984-0251.fw001

M . Joan Comstock, Series Editor Advisory Board Robert Baker

Geoffrey D. Parfitt

U.S. Geological Survey

Carnegie-Mellon University

Martin L. Gorbaty

Theodore Provder

Exxon Research and Engineering C o .

Glidden Coatings and Resins

Herbert D. Kaesz

James C. Randall

University of California—Los Angeles

Phillips Petroleum Company

Rudolph J. Marcus

Charles N. Satterfield

Office of Naval Research

Massachusetts Institute of Technology

Marvin Margoshes

Dennis Schuetzle

Technicon Instruments Corporation

Ford Motor Company Research Laboratory

Donald E. Moreland U S D A , Agricultural Research Service

Davis L. Temple, Jr. Mead Johnson

W. H . Norton J. T. Baker Chemical Company

Charles S. Tuesday General Motors Research Laboratory

Robert Ory U S D A , Southern Regional Research Center

C. Grant Willson I B M Research Department

Vida and Gordon; Conformationally Directed Drug Design ACS Symposium Series; American Chemical Society: Washington, DC, 1984.

Downloaded by 80.82.77.83 on May 21, 2018 | https://pubs.acs.org Publication Date: April 24, 1984 | doi: 10.1021/bk-1984-0251.fw001

FOREWORD The ACS SYMPOSIUM SERIES was founded in 1974 to provide

a medium for publishing symposia quickly in book form. The format of the Series parallels that of the continuing ADVANCES IN CHEMISTRY SERIES except that in order to save time the papers are not typeset but are reproduced as they are submitted by the authors in camera-ready form. Papers are reviewed under the supervision of the Editors with the assistance of the Series Advisory Board and are selected to maintain the integrity of the symposia; however, verbatim reproductions of previously published papers are not accepted. Both reviews and reports of research are acceptable since symposia may embrace both types of presentation.

Vida and Gordon; Conformationally Directed Drug Design ACS Symposium Series; American Chemical Society: Washington, DC, 1984.