Correction to “Highly Diastereoselective Synthesis of

Addition/Correction pubs.acs.org/JACS

Correction to “Highly Diastereoselective Synthesis of Tetrahydropyridines by a C−H Activation−Cyclization−Reduction Cascade” Simon Duttwyler, Colin Lu, Arnold L. Rheingold, Robert G. Bergman,* and Jonathan A. Ellman* J. Am. Chem. Soc. 2012, 134, 4064−4067. DOI: 10.1021/ja2119833 S Supporting Information *

Page 4065. Further analysis of the spectroscopic data for tetrahydropyidines 6k and 6q indicates that the isomers depicted in Table 2 are incorrect. In the protonation step, the presence of the ester functionality resulted in formation of the regioisomeric conjugated iminium intermediates. Reduction then resulted in the isomeric tetrahydropyridines shown below:

We are grateful to Shuming Chen, a graduate student in the Ellman laboratory, for carrying out the structural reassignment.

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ASSOCIATED CONTENT

S Supporting Information *

COSY NMR spectrum confirming the corrected alkene regioisomer. This material is available free of charge via the Internet at http://pubs.acs.org.

Published: August 12, 2014 © 2014 American Chemical Society

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dx.doi.org/10.1021/ja507742p | J. Am. Chem. Soc. 2014, 136, 11849−11849