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Correction to “Organocatalytic Enantioselective Intramolecular Oxa-Michael Reaction of Enols: Synthesis of Chiral Isochromene”. Biswajit Parhi, Ji...
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Correction to “Organocatalytic Enantioselective Intramolecular Oxa-Michael Reaction of Enols: Synthesis of Chiral Isochromene” Biswajit Parhi, Jitendra Gurjar, Suman Pramanik, Abhisek Midya, and Prasanta Ghorai* J. Org. Chem. 2016, 81 (11), 4654−4663. DOI: 10.1021/acs.joc.6b00565

T

he catalyst structure in Table 1 was omitted from the final publication. The full table is provided below.

Table 1. Optimization of the Reaction Conditions

entry

2

solvent

temp (°C)

time (h)

yieldb (%)

eec (%)

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

2a 2b 2c 2d 2e 2f 2g 2b 2b 2b 2b 2b 2bd 2be 2b

1,2-DCE 1,2-DCE 1,2-DCE 1,2-DCE 1,2-DCE 1,2-DCE 1,2-DCE toluene PhCl PhH CH3CN F3CCH2OHf 1,2-DCE 1,2-DCE 1,2-DCE

rt rt rt rt rt rt rt rt rt rt rt rt rt rt 10

4 4 4 4 4 4 4 4 4 4 4 4 4 4 4

3 42 16 12

79 94 91 78

21 10 29 38 36 22

87 89 94 92 87 81

9 43 36

94 86 92

a All of the reactions are carried out on 0.02 mmol scale. bThe conversion was calculated on the basis of 1H NMR spectroscopy of the crude reaction mixture using anisole as the internal standard. cEnantiomeric excess were determined by HPLC analysis on a chiral stationary phase. d5 mol % catalyst was used. e15 mol % catalyst was used. fCF3CH2OH is non-nucleophilic, as MeOH gave the exoacetal.12c

Published: September 22, 2016 © 2016 American Chemical Society

9520

DOI: 10.1021/acs.joc.6b02177 J. Org. Chem. 2016, 81, 9520−9520