Current Topic pubs.acs.org/biochemistry
Cryo-Electron Microscopy and the Amazing Race to Atomic Resolution Elad Binshtein and Melanie D. Ohi* Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States ABSTRACT: Cryo-electron microscopy (cryo-EM), the structural analysis of samples embedded in vitreous ice, is a powerful approach for determining three-dimensional (3D) structures of biological specimens. Over the past two decades, this technique has been used to successfully calculate subnanometer (
