CuS Nanodots with Ultrahigh Efficient Renal Clearance for Positron

Jun 22, 2015 - To test the cell killing induced by the photothermal effect through CuS NDs, 4T1 cells were incubated with CuS NDs for 2 h, washed, and...
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CuS Nanodots with Ultrahigh Efficient Renal Clearance for Positron Emission Tomography Imaging and Image-Guided Photothermal Therapy Min Zhou,† Junjie Li,† Su Liang,† Anil K. Sood,‡,§ Dong Liang,^ and Chun Li*,†,§ †

Department of Cancer Systems Imaging, ‡Departments of Gynecologic Oncology & Reproductive Medicine and Cancer Biology, and §Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States and ^Department of Pharmaceutical Sciences, Texas Southern University, Houston, Texas 77004, United States

ABSTRACT Translation of nanoparticles (NPs) into clinical practice has been limited by toxic effects

induced by nonspecific accumulation of NPs in healthy organs after systemic administration. The ideal NPs should accumulate in the target site, carry out their function, and then ultimately be eliminated from the body. Here, we show a single-compartment, multifunctional ultrasmall copper sulfide nanodot (CuS ND) that is rapidly cleared from the body. These CuS NDs have a hydrodynamic diameter of