Designer Surfactants: More Affordable and Convenient
Nok has comparable reactivity
OTBS
Grubbs-II (2 mol %)
Me
+ O
Me
room temperature, 12h
surfactant (2 wt % aq.)
OTBS
O
conversion (determined by 1H NMR)
PTS (698717) TPGS-750-M (733857) Nok (776033)
71% 77% 76%
Other Reactions Possible with Nok at Room Temperature
Aldrich has collaborated with Professor Bruce Lipshutz and coworkers to provide two new additions to our Designer Surfactant portfolio: ¥ Nok (776033), also known as SPGS-550-M, was designed from a more cost-effective amphiphile, which displays comparable reactivity to its predecessors PTS (698717) and TPGS-750-M (763896, 733857, 763918). This now provides the most affordable Designer Surfactant yet, and is offered as a 2% weight aqueous solution.
¥ ¥ ¥ ¥ ¥ ¥ ¥
Suzuki-Mayaura Cross-Coupling Negishi Cross-Coupling Miyaura Borylation Sonogashira Cross-Coupling Heck Reaction Stille Cross-Coupling Buchwald-Hartwig Amination
Boxed Reactions Available for a 1.0 mmol Experiment ¥ ¥ ¥ ¥
Buchwald-Hartwig Amination (747599) Heck Reaction (747904) Sonogashira Reaction (747912) Suzuki-Miyaura Cross-Coupling (747602)
¥ For your convenience, Aldrich has devised a kit with premeasured quantities for faster reaction setup. We now offer four kits on 1 mmol scale with written protocols on our website.
For a full listing of our Designer Surfactant portfolio please visit:
Aldrich.com/DesignerSurfactants
Reference: Klumphu, P.; Lipshutz, B. H. J. Org. Chem. 2014, 79, 888.
©2014 Sigma-Aldrich Co. LLC. All rights reserved. Aldrich and Sigma-Aldrich are registered trademarks of Sigma-Aldrich Co. LLC, registered in the US and other countries. Add Aldrich and Redi-Dri are trademarks of Sigma-Aldrich Co. LLC.
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