Anal. Chem. 2010, 82, 2463–2471
Development, Characterization, and Application of Paper Spray Ionization Jiangjiang Liu,†,‡ He Wang,‡ Nicholas E. Manicke,§ Jin-Ming Lin,*,† R. Graham Cooks,§,| and Zheng Ouyang*,‡,| The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, and Center for Analytical Instrumentation Development, Purdue University, West Lafayette, Indiana 47907 Paper spray is developed as a direct sampling ionization method for mass spectrometric analysis of complex mixtures. Ions of analyte are generated by applying a high voltage to a paper triangle wetted with a small volume (
