Preface Major changes in the synthesis and development of new agrochemicals has occurred in the past few years of the 20 century. Mergers and acquisitions within the industry have also changed the research environment. As we enter the 21 century, various agricultural biotechnological efforts are supplementing and replacing standard agrochemicals. However, the rise of biotechnology has not been without some controversy due to unresolved health concerns and political issues. Therefore, it is widely believed that traditional crop protection agents will play a major role in agriculture for some time to come. The editors of these volumes have organized synthesis symposia at each American Chemical Society (ACS) national meeting since 1984. These symposia have been sponsored by the A C S Division of Agrochemicals with the aim of providing chemists with a forum for presenting the synthesis and chemistry of new agrochemical agents. The current book has chapters taken from the symposia presented at the Las Vegas A C S National Meeting held in the summer of 1997 through the Washington, D C A C S National Meeting held in the summer of 2000. Each of the chapter authors was requested to present the current status of the work at the time of preparation of the manuscript. In many cases considerably more effort has been done since the work was presented at the meeting. These chapters present a unique look into the discovery process of our current and future agrochemical products. Not all of the chapters represent materials that will eventually be commercialized. It is hoped that these chapters will also provide a learning experience both for those working in this field and for others interested in the biological effects of organic molecules. As with the previous volumes, our goal is to inform the reader of the current trends in research for safe, efficient, biologically active agrochemicals. The organization of this book is similar to that of the preceding volumes. After the overview chapter, a section describes efforts in the discovery of new herbicides. The next section describes the discovery of new insecticides and highlights the discovery of and development of the new DuPont insecticide Indoxacarb. The final section deals with the control of plant fungal diseases.
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Acknowledgments We express our thanks to the authors and their employers who have shared with us the details of their interesting research results—first at the xi Baker et al.; Synthesis and Chemistry of Agrochemicals VI ACS Symposium Series; American Chemical Society: Washington, DC, 2001.
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symposia and then in going that extra mile to prepare the chapters for publication. We hope that you our readers—whether you are our fellow synthesis chemists, or microbiologists, entomologists, plant physiologists, biotechnologists, as well as medicinal and pharmaceutical chemists—will find the chapters interesting, useful, and above all stimulating! Last, but not least, we also wish to thank DuPont and Buckman Laboratories International, without their generous support of these symposia, this volume could not have been published.
Don R. Baker Consultant 15 Muth Drive Orinda, C A 94563
[email protected] Joseph G. Fenyes Buckman Laboratories International, Inc. 1256 North McLean Boulevard Memphis, TN 38108
[email protected] George P. Lahm Stine-Haskell Research Center DuPont Agricultural Products Building 300, P.O. Box 30 Newark, D E 19714-0030
[email protected] Thomas P. Selby Stine-Haskell Research Center DuPont Crop Protection Building 300, Room 126 P.O. Box 30 Newark, D E 19714-0030
[email protected] Thomas M. Stevenson Stine-Haskell Research Center DuPont Agricultural Products P.O. Box 30 Newark, D E 19714-0030
[email protected] xii Baker et al.; Synthesis and Chemistry of Agrochemicals VI ACS Symposium Series; American Chemical Society: Washington, DC, 2001.