Ebselen, a Seleno-organic Antioxidant, as an Electrophile Volume 19

Chem. Res. Toxicol. 2006, 19, 1557

Additions and Corrections Ebselen, a Seleno-organic Antioxidant, as an Electrophile [Volume 19, Number 9, September 2006, pp 1196-1204] TOYO SAKURAI, MASAYA KANAYAMA, TAKAHIRO SHIBATA, KEN ITOH, AKIRA KOBAYASHI, MASAYUKI YAMAMOTO, AND KOJI UCHIDA

We cited an article by Hong et al. ((2005) J. Biol. Chem. 280, 31768-31775) (ref 46) as the work that demonstrated that the C151 of Keap1 was one of the most readily modified cysteine residues by biotinylated iodoacetamide in Keap1 (Results, last line and Discussion, last paragraph). However, in the article by Hong et al., the authors characterized Keap1 ubiquitination and Nrf2 activation by electrophile adduction and demonstrated the adduction of thiol-reactive electrophiles to the central linker domain of Keap1. Therefore, it is obvious that we misrepresented the work by Hong et al. We sincerely apologize to the authors of the article and the readers of this journal for any confusion or inconvenience this may have caused. TX600268H 10.1021/tx0600268h Published on Web 11/01/2006

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