Gambieric acids: unprecedented potent antifungal substances isolated

Gambierone, a Ladder-Shaped Polyether from the Dinoflagellate Gambierdiscus belizeanus. Inés Rodríguez , Grégory Genta-Jouve , Carmen Alfonso , Kev...
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J. Am. Chem. SOC.1992, 114, 1102-1103

1102

Gambieric Acids: Unprecedented Potent Antifungal Substances Isolated from Cultures of a Marine Dinoflagellate Cambierdiscus toxicus

Chart I

Hiroshi Nagai 6

7

oxygen to one metallacycle a-carbon in the equatorial conformation. This new stereoelectronic effect can be attributed to a transannular interaction between an occupied metal spd hybrid orbital and the C8-C2 u* orbital (cf., 6, Chart I).'z The polarization of the C8