J. Am. Chem. SOC.1992, 114, 1102-1103
1102
Gambieric Acids: Unprecedented Potent Antifungal Substances Isolated from Cultures of a Marine Dinoflagellate Cambierdiscus toxicus
Chart I
Hiroshi Nagai 6
7
oxygen to one metallacycle a-carbon in the equatorial conformation. This new stereoelectronic effect can be attributed to a transannular interaction between an occupied metal spd hybrid orbital and the C8-C2 u* orbital (cf., 6, Chart I).'z The polarization of the C8
