EDITOR
Charles R. Bertsch, Manager, Editorial Production
HANS NEURATH, University of Washington AMERICAN CHEMICAL SOCIETY PUBLICATIONS
1155 Sixteenth Street, N.W., Washington, D. C. 20036 Richard L. Kenyon, Director of Publications ASSOCIATE EDITORS
Milton P. Gordon, University of Washington Edmond H. Fischer, University of Washington William W. Parson, University of Washington
EDITORIAL ADVISORY BOARD
Eric G. Ball, Harvard Medical School Clinton E. Ballou, University of California, Berkeley Paul D. Boyer, University of California, Los Angeles Herman Eisen, Washington University Heinz Fraenkel-Conrat, University of California, Berkeley Joseph S. Fruton, Yale University David K. Fukushima, Montefiore Hospital, New York Gordon G. Hammes, Cornell University John J. Holland, University of California, La Jolla William P. Jencks, Brandeis University Elwood V. Jensen, University of Chicago Irving M. Klotz, Northwestern University Henry A. Lardy, University of Wisconsin Albert L. Lehninger, Johns Hopkins University Peter Lengyel, Yale University Fritz A. Lipmann, Rockefeller University Alton Meister, Cornell University Medical College, New York Marshall W. Nirenberg, National Institutes of Health Mary Jane Osborne, University of Connecticut William D. Phillips, Du Pont Experimental Station Rodney R. Porter, Oxford University William J. Ray, Jr., Purdue University Howard K. Schachman, University of California, Berkeley Harold A. Scheraga, Cornell University Esmond E. Snell, University of California, Berkeley Herbert A. Sober, National Institutes of Health Earl R. Stadtman, National Heart Institute Charles C. Sweeley, Michigan State University Paul O. P. Ts'o, Johns Hopkins University Bert L. Vallee, Harvard Medical School Bernard Witkop, National Institutes of Health
SECRETARY OF THE BOARD
Warren E. C. Wacker, Harvard Medical School
2A
BIOCHEMISTRY,
VOL.
9, NO. 9,
1970
Joseph H. Kuney, Director of Business Operations Director of Publications Research David E. Gushee, Publication Manager, Journals
©Copyright, 1970, by the American Chemical Society. Published biweekly by the American Chemical Society at 20th and Northampton Streets, Easton, Pennsylvania. Second-class postage paid at Easton, Pennsylvania. Manuscripts for publication and correspondence regarding accepted papers should be sent to the Editor, Hans Neurath, University of Washington, Seattle, Washington 98105. Proof, edited manuscripts, and reprint orders should be sent to Editorial Production Office, American Chemical Society, 20th and Northampton Streets, Easton, Pa. 18042. Manager: Charles R. Bertsch. Senior Production Editor: Marianne C. Brogan. Assistant Editor: Patricia A. Bronko. Editorial Assistant: Margaret Sullivan. Advertising Office: Reinhold Publishing Corporation, 600 Summer Street, Stamford, Connecticut 06904. The American Chemical Society and the Editors of Biochemistry assume no responsibility for the statements and opinions advanced by contributors to this journal. Business and Subscription Information Remittances and orders for subscriptions and for single copies, notices of changes of address and new professional connections, and claims for missing numbers should be sent to the Subscription Service Department, American Chemical Society, 1155 Sixteenth Street, N.W., Washington, D. C. 20036. Changes of address for this journal must be received four weeks before the first issue is to go to the new address. Such notification should include both old and new addresses and ZIP code. Please enclose a mailing label from a copy of one of your ACS publications with your notification. Claims for missing numbers will not be allowed (1) if received more than sixty days from date of issue plus time normally required for postal delivery of journal and claim, (2) if loss was due to failure of notice of change in address to be received before the date specified in the preceding paragraph, or (3) if the reason for the claim is "missing from files." Subscription rates for 1970: to members, $20.00 per year; to nonmembers, $40.00 per year. Postage to Canada and countries in the Pan-American Union, $3.00; all other countries, $3.50. Single copies : for current year, $2.00. Rates for back issues and volumes are available from Special Issues Sales Department, 1155 Sixteenth St., N.W., Washington, D. C. 20036; This publication and the other ACS periodical publications are now available on microfilm. For information write to: MICROFILM, Special Issues Sales Department, American Chemical Society, 1155 Sixteenth St., N.W., Washington, D. Cj 20036.