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High-throughput simultaneous analysis of pesticides by supercritical fluid chromatography coupled to high-resolution mass spectrometry Takeshi Bamba J. Agric. Food Chem., Just Accepted Manuscript • Publication Date (Web): 29 Dec 2014 Downloaded from http://pubs.acs.org on January 4, 2015
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Journal of Agricultural and Food Chemistry
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High-throughput simultaneous analysis of pesticides by supercritical fluid chromatography coupled to highresolution mass spectrometry
Journal: Manuscript ID: Manuscript Type: Date Submitted by the Author: Complete List of Authors:
Journal of Agricultural and Food Chemistry jf-2014-056248 Article 20-Nov-2014 Ishibashi, Megumi; Osaka University, Izumi, Yoshihiro; Osaka University, Sakai, Miho; Miyazaki Agricultural Research Institute, Ando, Takashi; Miyazaki Agricultural Research Institute, Fukusaki, Eiichiro; Osaka University, Dept. Biotechnology, Graduate School of Enginering Bamba, Takeshi; Osaka Univ., Biotechnology
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Journal of Agricultural and Food Chemistry
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TITLE
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High-throughput simultaneous analysis of pesticides by supercritical fluid
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chromatography coupled with high-resolution mass spectrometry
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AUTHORSHIP
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Megumi Ishibashi,† Yoshihiro Izumi,† Miho Sakai,†, ‡ Takashi Ando,‡ Eiichiro Fukusaki,† and
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Takeshi Bamba*,†
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†
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Yamadaoka, Suita, Osaka 565-0871, Japan
Department of Biotechnology, Graduate school of Engineering, Osaka University, 2-1
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‡
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880-0212, Japan
Miyazaki Agricultural Research Institute, 5805 Shimonaka, Sadowara-cho, Miyazaki
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Corresponding Author
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*(T.B.) Phone/Fax: +81-(0)6-6879-7418. E-mail:
[email protected].
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ABSTRACT
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Recently, a generally applicable screening method for multiresidue pesticide analysis, which
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is simple, quick, accurate, and has a reliable performance, is becoming increasingly important
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for food safety and international trade. Here, we have proposed a high-throughput screening
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methodology that enables the detection of multiresidue pesticides using supercritical fluid
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chromatography coupled to a high-performance benchtop quadrupole Orbitrap mass
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spectrometry (SFC/Q Exactive) and an automated library-based detection. A total of 444
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chemicals covering a wide polarity range (logPow from ‒4.2 to 7.7) and a wide molecular
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weight range (from 99.0 to 872.5) were analyzed simultaneously through a combination of
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high mass resolution (a value of m/∆m = 70,000), high mass accuracy (
