How Does Product Isotope Effect Prove the Operation of a Two-State

How Does Product Isotope Effect Prove the Operation of a Two-State “Rebound” Mechanism in C−H Hydroxylation by Cytochrome P450? [J. Am. Chem. So...
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How Does Product Isotope Effect Prove the Operation of a Two-State “Rebound” Mechanism in C-H Hydroxylation by Cytochrome P450? [J. Am. Chem. Soc. 2003, 125, 13024-13025]. Devesh Kumar, Samue¨l P. de Visser, and Sason Shaik* Page 13025. The first label (1-D2H) in Table 1 was misspelled. It should read 1-DH2. The semiclassical KIE data for 1-D2H at 303 K are KIEHS ) 5.61 and KIELS ) 6.04. JA040802K Published on Web 02/25/2004

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10.1021/ja040802k CCC: $27.50 © 2004 American Chemical Society