Chemical Reviews, 2002, Vol. 102, No. 2 7A
In Color on the Front Cover (Top left) Glycodendiproteins: Just one example of the novel biomolecules that are accessible through glycoprotein synthesis. See “Synthesis of Glycoproteins” by Benjamin G. Davis, p 579. (Bottom left) Overlay of individual snapshots taken at 100 ps intervals. The glycan arms are color coded (dark blue, Man3G1cNAc2 core; light blue, 3-arm; green and yellow, two 6-arms). The overall topology of the molecule is well preserved given the high degree of flexibility for each individual linkage. See “Conformational Studies of Oligosaccharides and Glycopeptides: Complementarity of NMR, X-ray Crystallography, and Molecular Modelling” by Mark R. Wormald, Andrei J. Petrescu, Ya-Lan Pao, Ann Glithero, Tim Elliott, and Raymond A. Dwek, p 371. (Right) Side view of hexameric C1q. See “Glycosylation and the Complement System” by Gayle E. Ritchie, Beryl Moffat, Robert B. Sim, B. Paul Morgan, Raymond A. Dwek, and Pauline M. Rudd, p 305. In Color on the Inside Front Cover (Middle left) Interactions between noeuromycin and substrate phosphate (Pi) and protein groups at the catalytic site of glycogen phosphorylase b (GPb). Details of the phosphate and cofactor pyridoxal 5′-phosphate (PLP) contacts in the GPb−noeuromycin−Pi ternary complex. Hydrogens are indicated as dashed lines; W represents water molecules. The structure of the ternary complex was determined at 2.26 Å resolution. Courtesy of N. G. Oikonomakos, M. Kosmopoulou, D. D. Leonidas, and E. D. Chrysina, National Hellenic Foundation, Greece. See “Recent Developments of Transition-State Analogue Glycosidase Inhibitors of Non-natural Product Origin” by Vinni H. Lillelund, Henrik H. Jensen, Xifu Liang, and Mikael Bols, 515. (Bottom left) X-ray crystal structure of concanavalin A spanned by bivalent mannosyl dendrimer. Monomeric protein units are colored in blue and red, corresponding to separate tetrameric protein assemblies with the spanning ligand colored according to atomic composition. See “The Cluster Glycoside Effect” by Joseph J. Lundquist and Eric J. Toone, p 555. In Color on the Inside Back Cover Isothermal titration calorimetric profiles of concanavalin A in the presence of carbohydrate ligands with different affinities. Structures of a trimannoside carbohydrate ligand and its bivalent analogue, and the X-ray structures of the lectin complexed with the trimannoside. See “Thermodynamic Studies of Lectin−Carbohydrate Interactions by Isothermal Titration Calorimetry” by Tarun K. Dam and C. Fred Brewer, p 387.
