Industrial-Academic Interfacing - ACS Publications - American

Antitrust laws, and cooperative research, 39. B. Barriers to harmonious relationship, 8. Basic research corporate and government support, 22,30-31,46-...
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Cape, Ronald E., 41 Gehrke, Charles W., 21 Kruytbosch, Carlos E., 37,105 Lanman, Robert C , 13 McClelland, Alan L., 59 Meisels, G. G., 5

M i l l e r , Lowell D., 1 Runser, Dennis J . , 13 Tabor, Theodore E., 29 Teich, Judith L., 67 Yankwich, Peter E., 51 Zumwalt, Robert W., 21

Subject Index A Academic and i n d u s t r i a l chemistry, h i s t o r i c a l overview, 6-7,21 Academic c o n s u l t i n g , and technology transfer, 9 Academic mandate, and cooperative research, 23 Academic research, chemical, d e c l i n i n g support, 5 Academic-industrial complex, soc a l l e d , and issues i n cooperative research, 46 American Chemical Society and academic-industrial r e l a t i o n s , 36 concordance project and Graduate Directory, 8-9 A l i e n a t i o n , industrial-academic, 5,7 A n t i t r u s t laws, and cooperative research, 39 B B a r r i e r s to harmonious r e l a t i o n s h i p , 8 Basic research corporate and government support, 22,30-31,46-47 necessity f o r maintaining, 21,27 Bibliography, cooperative research arrangements, 107-154 B i o l o g i c a l sciences i n commercial biotechnology, 4 5 Biotechnology, i n d u s t r i a l v s . academic values, 41 Block grants to i n s t i t u t i o n s , issues, 43,45-46 C Cal Tech-Dupont Company, cooperative research arrangement, 74t-75t,80 Campus unrest, and academic-industrial connection, 7

Chemical co-op, d i r e c t o r y , 91-105 Council f o r Chemical Research, f i l e of f a c u l t y research students, 8 CCR—See Council f o r Chemical Research (CCR) Chemical co-op, d i r e c t o r y , 91-105 Chemical research, academic, and issues, 5 Atomic Energy Commission support, 6 mission-oriented Federal agencies support, 6,10 Navy support, 6 Chemical Research Fund, formula f o r support of academic chemistry, 11 Chemical Science and Engineering Fund Chemistry i n industry, from academic and industry perspectives, 10 Commercial development of research f i n d i n g s , 41,42,45 Competition w i t h i n the u n i v e r s i t y , 42,44 C o n f i d e n t i a l i t y of f i n d i n g s i n industry-supported academic research, 42,44-45 C o n f l i c t of i n t e r e s t i n industrysupported academic research, 42 Consulting, academic, 1-9 b e n e f i t s , 2-3 industry a t t i t u d e toward, 2 "not invented here" syndrome, 1-2 and technology t r a n s f e r , 9 Cooperative research arrangements academic and i n d u s t r i a l expectations, rewards, and problems, 21-28 academic chemical research, 5 and academic mandate, 23 academic motivations, 38-39 analyzed i n National Science Board studies, 37-40 annotated bibliography, 107-154 and a n t i t r u s t laws, 39 block grants to u n i v e r s i t i e s , 45 chemical co-op, d i r e c t o r y , 91-105

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Cooperative research arrangements— Continued c o l l e c t i v e arrangements, u n i v e r s i t y and several corporations, 38 common features of successful programs, 22 as c o n f l i c t or reinforcement, 5-11 contracts, 43 corporation as i n i t i a t o r , 38 corporations and u n i v e r s i t i e s , 76-80 and c r e a t i v e process, 41,42-44 Dow Chemical Company approaches, 29-36 f a c u l t y and industry, cooperative research arrangement, 74t-75t,86-88 fellowships, Dow Chemical Company, 36 goals, 25 h i s t o r i c a l overview, 6-7,21 i d e n t i f i c a t i o n of academic research programs, Dow Chemical Company, 33 i n d u s t r i a l and academic perceptions of b e n e f i t s , 23 industry motivations f o r , 39 improvements i n , 5 i n d i v i d u a l grant or contract, 18,38,42-43 and i n d u s t r i a l goals, 23 industry motivations f o r , 38 inventory, 73-89 and massive industry grants, 41-43 and molecular and c e l l biology, 42 mutually i n i t i a t e d , 38 new ideas and technology as industry motive, 38 nonprofit i n s t i t u t i o n s and industry, 74t-75t,84 patterns of connection, 40 personnel a c q u i s i t i o n as industry motive, 38 i n pharmacology and pharmaceutical technology, 16 philanthropy, i n d u s t r i a l , 38 p r i o r connections between p a r t i e s , 37 problems f o r academic i n s t i t u t i o n , 24-25 program to improve e f f e c t i v e n e s s of u n i v e r s i t y research, 21 public vs. private educational i n s t i t u t i o n s , 23 Research Council Plan f o r funding cooperative research, 26-27 rewards f o r academia, industry, 23-24,36 i n toxicology, 16

Cooperative research arrangements— Continued UMKC-Marion Laboratories experiment, 13-19 u n i v e r s i t y as i n i t i a t o r , 38 u n i v e r s i t y and several corporations, 38 C o r n e l l University-Procter and Gamble, cooperative research arrangement, 74t-75t,80 Corporate grants to u n i v e r s i t i e s , 76-80 Council f o r Chemical Research current a c t i v i t i e s , 11 d i r e c t o r y , 67-71 history, 6 goals, 32,33f Creative process, and cooperative research, 41-42,44 D Directories chemical co-op, 91-105 Council f o r Chemical Research DNA Sciehce-E. F. Hutton-Weizman I n s t i t u t e - B a t t e l l e Memorial Institute-Baxter Laboratories, cooperative research arrangement, 74t-75t,85-86 Dow Chemical Company and cooperative research, 29-36 and Dow Chemical Company Foundation, 30-31 E Exclusive l i c e n s i n g r i g h t s , 44 Expectations of s c i e n t i s t s i n cooperat i v e research, 22-23 F Facilities industry-provided, 25-26 u n i v e r s i t y , access to as industry motive f o r cooperative research, 39 Federal government support f o r research mission-oriented agencies, 6,10 r o l e i n academic-industrial partnership, 8 i n d i v i d u a l research support, 9 Food and Drug Administration, and Marion Laboratories p r o j e c t , 17 Foreign patent r i g h t s , and p u b l i c a t i o n c o n s t r a i n t s , 46

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INDEX Free exchange of information, as issue i n cooperative research, 41-42,46 Funding academic research and Chemical Science and Engineering Fund (CSEF), 32 and Dow Chemical Company Foundation, 30-31 and Federal support f o r basic science, 47 and need f o r supplemental approaches, 21-22 and Small Business Innovation Research Program, 27 and U n i v e r s i t y of Missouri-Columbia, 26 and Upjohn Company approach, 16-17 Future of academic-industrial r e l a t i o n s h i p , 11

I n s t i t u t i o n a l d i f f e r e n c e s , industry and academia, 39 Instruments, industry-provided, 25-26 I s o l a t i o n of academia, as b a r r i e r to technology t r a n s f e r , 9 Issues i n corporation-sponsored research, 24-25 academic perspective, 39 b i o l o g i c a l sciences and chemistry, 45 commercialization, 41-42 c o n f i d e n t i a l i t y , 42 industry perspective, 39 free exchange of ideas, 41-42 patent r i g h t s , p r o t e c t i o n , 39 prepublication review, 43 proprietary information, protection, 39 salary equity, 9

G K Genentech, cooperative research arrangement, 88 Genetics I n s t i t u t e , cooperative research arrangement, 88 Genetics Systems Company (Geneco), cooperative research arrangement, 88 Goals, i n d u s t r i a l and academic, and possible c o n f l i c t , 41-49 Graduate education, goals, 13 H Harvard U n i v e r s i t y , cooperative research arrangements, 74t-75t,76-79 History of academic-industrial r e l a t i o n s h i p , 6-7,21 Hoechst-Massachusetts General, cooperative research arrangement, 45 I Individual grants, Marion Laboratories, 18 I n d u s t r i a l and academic chemistry, h i s t o r i c a l overview, 6-7,21 I n d u s t r i a l chemistry, from academic and industry perspectives, 10 I n d u s t r i a l goals, and cooperative research, 23 Industry grants, and commercialization, 43 Influence of chemical industry on academia, 6 I n s t i t u t e f o r Chemical Education, proposed, 8

Kansas University-Merck Corporation, cooperative research arrangement, 87 L L i b e r a l arts values, and academicindustrial relationship, 8 "Library o f instruments" plan, industry-provided f a c i l i t i e s , 25-26,27 Licensing, as problem i n cooperative research, 39 M

Manhattan Project, and academici n d u s t r i a l connection, 6 Marion Laboratories-UMKC experimental residency program, 17 Maryland, U n i v e r s i t y of, and Dupont Company, cooperative research arrangement, 74t-75t,79-80 Massachusetts General Hospital-Hoechst Chemical, cooperative research arrangement, 74t-75t,77-78 Missouri, U n i v e r s i t y of at Columbia, and research support, 26 at Kansas C i t y experimental residency program with Marion Laboratories, 13-19 and v i s i t i n g professorships, 13 MIT, cooperative research arrangements, 74t-75t,79,80 Molecular and c e l l "biology, and industrial-academic r e l a t i o n s h i p s , 42

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National I n s t i t u t e s of Health, support f o r basic research, 6,22 National Science Board (NSB) 14th Annual Report, some p r o v i s i o n a l s t a t i s t i c s , 37 studies i n u n i v e r s i t y - i n d u s t r y research r e l a t i o n s h i p s , 37-40 National Science Foundation, support f o r basic research, 6,10,22 Needs i n cooperative research, i n d u s t r i a l and academic, 7-9 0 Ohio University-Genetic Engineering, Inc., cooperative research arrangement, 74t-75t,82-83 P Patent r i g h t s , p r o t e c t i o n of, as issue i n cooperative research, 39,43,46 Patterns of i n d u s t r y - u n i v e r s i t y connection, scenario, 40 Pharmaceutical industry, 13 and commercial use of research f i n d i n g s , 41 proposed patent l e g i s l a t i o n , 44 t r a i n i n g needs, 13 Philanthropy, i n d u s t r i a l , and research r e l a t i o n s h i p s , 38 Prepublication review, as issue i n cooperative research, 39,43 Private u n i v e r s i t i e s , and cooperative research, 23 Proprietary information and r i g h t s protection, issue i n cooperative research, 39,44,46 Protection of patent r i g h t s , 39,46 Public academic i n s t i t u t i o n s , and cooperative research, 23 R R&D—See Research ard development Recombinant DNA technology, Stanford patent, 44 Research and development from academic perspective, 13-19 residency program, UMKC-Marion Laboraties, 13-19 Research contracts and patent r i g h t s , 43 review period p r o v i s i o n s , 43 r o y a l t y agreements, 43 Research Council Plan (RCP) f o r cooperative research, 26-27

Research f a c i l i t i e s , industryprovided, 25-26 Responsibility to support basic research, corporate, 46-47 Rewards of cooperative research, 23-24,36 Royalty agreements, 43 S Sabbaticals, of academics i n industry, 18 Salary equity, as i s s u e , 9 Salk I n s t i t u t e - P h i l l i p s Petroleum, cooperative research arrangement, 74t-75t,84-85 Scripps C l i n i c and Research Foundation-Johnson & Johnson, cooperative research arrangement, 74t-75t,85 Seaborg, Glenn T., on r e l a t i o n s h i p of u n i v e r s i t y to basic research, 21 Semiconductor Research Cooperative, 39 Small Business Innovation Research Program, Federal funding measure, 27 Stanford patent, recombinant DNA, Herbert Boyer and Stanley Cohen, 44 Stanford University-UC Berkeley-Engenics, cooperative research, 74t-75t,81-82 Symbiosis, industry and academia, 41 T Technology t r a n s f e r , d i f f i c u l t i e s , 8 Tufts U n i v e r s i t y Medical School-Micromole, cooperative research arrangement, 87-88 U UC D a v i s - A l l i e d Chemical Corporation, cooperative research arrangement, 74t-75t,8l UMKC—See a l s o U n i v e r s i t y of Missouri-Kansas C i t y University as unrecognized resource, 3 University Genetics (Ugen), cooperat i v e research arrangement, 83-84 University of Maryland—See Maryland, University of U n i v e r s i t y of M i s s o u r i — S e e Missouri, University of University of Wisconsin—See Wisconsin, U n i v e r s i t y of University r e l a t i o n s , Dow Chemical Company approach, 30

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University-Industry Research Conference, Midland, Mich., 1979, 32 Upjohn Company, approach to academic research funding, 16-17 V Values academic, broadened by i n t e r a c t i o n with industry* 11

Values—Continued i n d u s t r i a l and academic, compared, 39,41-49 V i s i t i n g professor programs, 13

Washington University-Malinckrodt, Inc., 74t-75t,80-84 Wisconsin, U n i v e r s i t y o f , and CetusAgrigenetics, cooperative research arrangement, 87

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Biographies

of Authors

RONALD E. CAPE i s cofounder and chairman of Cetus Corporation, a biotechnologyf i r m . He earned an A.B. i n chemistry at Princeton, an M.B.A. at Harvard Business School, and a Ph.D. i n biochemistry a t M c G i l l . Dr. Cape did postdoctoral research a t the Molecular Biology and Virus Laboratory a t the U n i v e r s i t y of C a l i f o r n i a , Berkeley. He i s 1978-79 Foundation f o r Microbiology l e c t u r e r of the American Society f o r Microbiology; a member of the Advisory Council to the Department of Biochemical Sciences, Princeton U n i v e r s i t y ; and a member of the Rockefeller U n i v e r s i t y Council. Dr. Cape i s a l s o adjunct professor of business administration a t the U n i v e r s i t y of Pittsburgh and a member of the board of d i r e c t o r s of S c i e n t i f i c American, Inc., and of Neutrogena Corporation. CHARLES W. GEHRKE i s professor of biochemistry and manager of the Experiment Station Chemical Laboratories a t the U n i v e r s i t y of Missouri i n Columbia. In a d d i t i o n to teaching and research, he i s state chemist f o r the State of Missouri. He received h i s B.A. degree from Ohio State U n i v e r s i t y , a B.S. degree i n education, and an M.S. degree. From 1941 to 1945 he was professor and c h a i r man of the department of chemistry a t Missouri Valley College, returning to Ohio State U n i v e r s i t y as an i n s t r u c t o r i n biochemistry and r e c e i v i n g a Ph.D. degree. Dr. Gehrke was president-elect of the American Chemical Society and i s on i t s Board of D i r e c t o r s ; he a l s o i s a c t i v e i n the Association of O f f i c i a l A n a l y t i c a l Chemists. His research i n t e r e s t s include the development of quantitative gas, high r e s o l u t i o n l i q u i d chromatographic, and automated spectrophotometric methods. He received the annual AOAC Harvey W. Wiley award i n a n a l y t i c a l chemistry and the ACS Kenneth A. Spencer award f o r achievement i n a g r i c u l t u r a l and food chemistry. CARLOS E. KRUYTBOSCH i s a s t a f f associate i n the National Science Foundation O f f i c e of Planning and P o l i c y Analysis and i s executive secretary of the National Science Board (NSB) Committees on the 12th and 14th NSB Reports. He has a l s o served as executive secretary of the NSB Committee on M i n o r i t i e s and Women i n Science. Dr. Kruytbosch i s a s o c i o l o g i s t , a holder of the Ph.D. from the University of C a l i f o r n i a at Berkeley, an has done undergraduate work and the U n i v e r s i t y of B r i t i s h Columbia i n Canada and the U n i v e r s i t y of Amsterdam i n the Netherlands. His p r i n c i p a l f i e l d s of i n t e r e s t are i n organization theory; science p o l i c y ; the sociology of science, of occupations, and of professions; and research administration. He edited a book on "The State of the U n i v e r s i t y . " Dr. Kruytbosch has taught at the Berkeley and Davis campuses of the U n i v e r s i t y of C a l i f o r n i a , a t the U n i v e r s i t y of Idaho, and a t the State U n i v e r s i t y of New York i n B u f f a l o . ROBERT C. LANMAN received a B.S. degree i n pharmacy from the U n i v e r s i t y of Minnesota. A f t e r p r a c t i c i n g as a community pharmacist, he returned to the U n i v e r s i t y and received a Ph.D. degree i n biochemical pharmacology. He presently serves as professor of pharmacology and medicine i n the schools of pharmacy and medicine of the U n i v e r s i t y of Missouri-Kansas C i t y . Dr. Lanman was a fellow of the American Foundation f o r Pharmaceutical Education, and held a s t a f f pharmacologist appointment i n the Laboratory of Chemical Pharmacology of the National Heart I n s t i t u t e , National I n s t i t u t e s of Health. His research i n t e r ests include the adsorption, d i s t r i b u t i o n , metabolism, and excretion of chemical substances i n animals and humans. He i s a member of the American Society f o r Pharmacology and Experimental Therapeutics, New York Academy of Sciences, Academy of Pharmaceutical Sciences, Federation of American S o c i e t i e s f o r Experimental Biology, and American Association of Colleges of Pharmacy.

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ALAN L. MCCLELLAND i s personnel administrator, Central Research and Development Department, Du Pont Company, at Experimental Station i n Wilmington, Del. In t h i s p o s i t i o n he has helped develop v i s i t i n g s c i e n t i s t , co-op education, and other academic-industrial i n t e r a c t i o n programs, as w e l l as being involved i n r e c r u i t i n g , career planning, and organization development. His previous Du Pont positions include campus r e c r u i t e r and research chemist. He has a l s o been i n s t r u c t o r i n the department of chemistry, U n i v e r s i t y of Connecticut, and vice president f o r engineering, Cherry-Burrell Corporation. His educational background includes a B.S. i n general engineering from Northwestern U n i v e r s i t y , a Ph.D. i n inorganic chemistry from the University of I l l i n o i s , and postdoctoral research at the U n i v e r s i t y of Birmingham, England. His American Chemical Society a c t i v i t i e s have included work on the Economic Status Committee, the Education Committee, and task forces on Manpower P o l i c y and Compensation of Employed Inventors. G. G. MEISELS attended the Gymnasium and the U n i v e r s i t y of Vienna and was awarded Fulbright and Smith-Mundt fellowships to continue h i s studies at the University of Notre Dame, where he received an M.S. and a Ph.D. i n i n chemistry. He worked f o r Gulf O i l Corporation i n Pittsburgh and f o r Union Carbide i n New York before j o i n i n g the U n i v e r s i t y of Houston as associate professor, then professor, and f i n a l l y department c h a i r . He moved to the University of Nebraska-Lincoln as professor and c h a i r of the chemistry department, and he i s now dean of the College of Arts and Sciences there. Dr. Meisels' research has been p r i m a r i l y i n mass spectrometry. His research has been supported by the National Science Foundation, the Robert A. Welch Foundation, and h i s current sponsor the Department of Energy. Vice chairman and chairmane l e c t of the Southeast Texas Section of ACS, Dr. Meisels has served on that society's Committee on Economic Status, which he now c h a i r s . He chaired the ACS task force that wrote "Women Chemists 1980." He has given a number of lectures on employment and employment projections, was elected a d i r e c t o r of the Council f o r Chemical Research, and chairs the Subcommittee on the Faculty Data Base. He i s a charter member and former committee chair of the American Society f o r Mass Spectrometry, and c u r r e n t l y i s a candidate f o r the e l e c t i v e p o s i t i o n of vice president f o r programs and p r e s i d e n t - e l e c t . LOWELL D. MILLER i s vice-president of corporate research and development f o r Marion Laboratories, Inc., i n Kansas C i t y , Mo. Dr. M i l l e r received a B.S. degree i n animal science, an M.S. i n p h y s i o l o g i c a l chemistry, and a Ph.D. i n biochemistry from the U n i v e r s i t y of M i s s o u r i . He has a l s o received board c e r t i f i c a t i o n through the American I n s t i t u t e of Chemists and from the American Board of C l i n i c a l Chemists. He has been president of the experimental biology laboratory and t e c h n i c a l d i r e c t o r f o r Smith, K l i n e , i n St. Louis, Mo.; associate d i r e c t o r of biomedical research f o r Warren-Teed Pharmaceuticals; and d i r e c t o r of b i o l o g i c a l research, biochemistry, and toxicology f o r N i e s l e r Laboratories, Inc. Dr. M i l l e r has served on the board of d i r e c t o r s of the Children's Hospital Committee i n Columbus, Ohio, and on the Pharmaceutical Manufacturer's Association committee f o r c l i n i c a l study guidelines f o r g a s t r i c a n t i s e c r e t o r y agents. He i s a member of the American Society of C l i n i c a l Chemistry, the International Society of Forensic S c i e n t i s t s , and the Society of Toxicology. DENNIS J . RUNSER i s d i r e c t o r of chemical a f f a i r s f o r Marion Laboratories, Inc., Kansas C i t y , Mo. His r e s p o n s i b i l i t i e s include a n a l y t i c a l and b i o a n a l y t i c a l research, s t a b i l i t y t e s t i n g , synthesis, pharmacokinetics, and b i o a v a i l a b i l i t y studies. He received h i s B.S. degree i n chemistry from I l l i n o i s Benedictine College and h i s Ph.D. from the U n i v e r s i t y of Iowa. He i s a l s o c u r r e n t l y adjunct professor on the f a c u l t y of the U n i v e r s i t y of Missouri-Kansas C i t y . Dr. Runser i s named i n "Who's Who i n the Midwest" and i s a c e r t i f i e d as a p r o f e s s i o n a l chemist by the American I n s t i t u t e of Chemists. He has held management positions i n q u a l i t y c o n t r o l and a n a l y t i c a l research with G. D. Searle & Company and the

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G i l l e t t e Company. He i s a member of the American Chemical Society, where he i s chairman-elect of the D i v i s i o n of Professional Relations and chairman of several l o c a l committees; a fellow of the American I n s t i t u t e of Chemists; a member of the National C e r t i f i c a t i o n Commission i n Chemistry and Chemical Engineering; a member of the National Conference on Pharmaceutical Analysis Planning Committee; and a member of the Chicago Chromatography, where he teaches annually at the HPLC t r a i n i n g school. Dr. Runser has published, lectured, and developed course materials i n the areas of career development f o r chemists, laboratory management, plasma emission spectroscopy, pharmacokinetics, and HPLC, including the textbook "Maintaining and Troubleshooting HPLC Systems: A User's Guide." THEODORE E. TABOR i s a native of Montana, where he obtained a B.A. degree i n chemistry from the University of Montana-Missoula. He was a National Defense Education Act fellow at Kansas State U n i v e r s i t y , where he obtained h i s Ph.D. degree i n chemistry. He joined the Dow Chemical Company i n Midland, Mich., and has held various positions i n Dow's R & D organization, a part of corporate R & D. His research areas include organic r e a c t i o n mechanisms, a p p l i c a t i o n s of chlorinated solvents i n t e x t i l e processing, and the development of flame r e t a r dants f o r t e x t i l e s and p l a s t i c s . He i s a member of the ACS and has held numerous positions i n the Midland Section, including the chairmanship of the s e c t i o n . JUDITH L. TEICH i s program evaluator f o r the Prince William County Community Mental Health Center i n Manassas, Va. After years as a c l i n i c i a n both i n the U.S. and i n I s r a e l , an i n t e r e s t i n p o l i c y and evaluation l e d her to a residency i n mental health research at St. Elizabeth's Hospital i n Washington, D.C. She has been a freelance consultant as well as an e d i t o r . She holds degrees i n English and i n s o c i a l work from Boston U n i v e r s i t y and New York U n i v e r s i t y , and i s a doctoral candidate at the C i t y University of New York. PETER E. YANKWICH i s professor of chemistry at the Urbana campus of the University of I l l i n o i s . He received a Ph.D. from the U n i v e r s i t y of C a l i f o r n i a at Berkeley. Among h i s q u a l i f i c a t i o n s to comment on industrial-academic r e l a t i o n s are long service i n ACS educational a f f a i r s , as a member of that society's Committee on Education and as chairman of i t s predecessor bodies; several i n d u s t r i a l consultantships; membership on the Advisory Council on College Chemistry; and the choice by most of h i s doctoral students of careers i n chemic a l industry. Dr. Yankwich i s an elected member of the ACS Board of D i r e c t o r s . ROBERT W. ZUMWALT received a B.S. i n chemistry from Southwest Missouri State University and a Ph.D. i n a n a l y t i c a l biochemistry from the University of Missouri. His graduate and postdoctoral research included a n a l y s i s of the returned lunar samples from Apollo missions 11-17. His research i n t e r e s t s include development and a p p l i c a t i o n of chromatographic techniques i n the area of a n a l y t i c a l biochemistry. Currently Dr. Zumwalt i s e d i t i n g and contributing to "Amino Acid Analysis by Gas Chromatography" with Professor Gehrke and Kenneth Kuo.

Runser; Industrial-Academic Interfacing ACS Symposium Series; American Chemical Society: Washington, DC, 1984.