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Intelligent LC Maximizes Productivity Using Automated Application Switching UltiMate 3000 Intelligent LC systems with Chromeleon® chromatography management software enable laboratories to automate different LC methods on one system, significantly increasing use time. Application switching automatically alternates between applications for optimal productivity and convenience. This technique uses automated smart routines to ensure an instrument automatically switches to a different analytical method, even if it involves a different mobile phase and HPLC column. For example, the switching thoroughly purges the autosampler, directing the purge outlet to waste when alternating from one application to another. Intelligent LC knows when to switch between valves and columns for uninterrupted, automated performance with no user involvement. A good example of application switching is impurity profiling using two markedly different methods (results shown in the chromatograms
below). One method monitors insulin following a USP procedure, requiring a 300-A stationary phase and a shallow gradient over 80 minutes. The second method is a stability study of 17-medroxyprogesterone on a 120-A stationary phase. Intelligent LC allows both methods to run overnight on the same system, increasing instrument use time. Application #1 runs with a highly concentrated sulfate buffer (pH 2.3) and acetonitrile, while application #2 uses a diluted acetate buffer (pH 5.0) and methanol. With dual-ternary pump technology and the option of flushing all lines of the autosampler, the automatic method switching is performed with a strictly controlled procedure. Chromatographers use uptime as a reliability indicator, but uptime is not the only important requirement. Equally significant is use time to maximize instrument load and production of useful data. Application switching leaves the original applications untouched and can be achieved with minimal effort, while fully documenting each method and transition for regulatory compliance.
'Show me a lab striving for superior results, convenience, and compliance.
and I'll show you a lab using Intelligent LC automation for instrument control.'1
Now you can automate advanced LC techniques requiring minimal user involvement with Chromeleon. Chromeleon's powerful data processing tools and spreadsheet-based reporting allow you to quickly calculate and share chromatography results. These tools even simplify the comparison of results against specifications. By reducing the need to export raw data for analysis with a third-party application, Chromeleon reduces your processing and reporting times by up to 98%.
Automated Switchover
Application #2
Now, that's productivity.
DI0NEX Using Intelligent LC application switching, laboratories can automate two markedly different methods, such as a USP insulin application (left) and a faster 17-medroxyprogesterone application (right), achieving excellent results. One system can alternate between the methods for unattended operation, greatly increasing productivity and convenience, and maintaining regulatory compliance. REQUEST MORE AT ADINFONOW.ORG
Passion. Power. Productivity. www.dionex.com •^2006 Dtonex Corp PIN 894 Chromeleon is a registered trademark of Dionex Corporation.
