Interfacing Analytical Chemistry and Clinical Chemistry - Analytical

NEWS AND VIEWS

Interfacing Analytical Chemistry and Clinical Chemistry 25th Annual Summer Symposium on Analytical Chemistry, June 14 to 16, 1972, Bellingham, WA

WESTERN

WASHINGTON

State Col-

" lege a t Bellingham, WA, is t h e site of the 25th Annual Summer Symposium on Analytical Chemistry. T h e college is located on a hillside overlooking the Bellingham city and b a y 90 miles n o r t h of Seattle and 22 miles south of t h e Canadian border. This year's symposium dealing with the interface between analytical and clinical chemistry is sponsored b y t h e ACS Analytical Chemistry Division, Analytical Chemistry journal, and H y cel, Inc., of Houston, T X . T h e scientific program will highlight scientific medical and laboratory research, education, a n d projections of clinical laboratory needs. Speakers have been drawn from university and N I H administrative staffs, medical researchers, and researchers in the basic disciplines of biochemistry, analytical chemistry, a n d zoology. Discussion will be on educational considerations for undergraduate, graduate, and postgraduate levels. T h e role of the N a tional Institutes of Health in developing these programs will also b e discussed. Other talks will b e d e voted t o the presentation of analytical chemistry research in the general areas of trace element analysis a n d thermometric measurements. T h e potential utility of these measurements in obtaining new medical knowledge and differentiation between health and disease will be considered. Progress in current medical research will be reviewed b y two physicians in other sessions. As laboratory scientists, each of these men will present his work and his perspectives on analytical-clinical chemistry as it relates CIRCLE 189 ON READER SERVICE CARD

to the clinical laboratory. Under consideration will be fundamental biochemical research of the three-dimensional structure of proteins and how enzyme function can b e altered b y carefully controlled and highly specific chemical modifications. Also, studies will b e presented on biologically active substances, such a s hormones and steroids, using radioimmuno assay techniques. The use of radioimmuno techniques for research a n d service commitments in the clinical chemistry laboratory will be discussed. T h e technical sessions will b e held in t h e Viking Union Wednesday morning a n d afternoon, Thursday morning a n d evening, a n d Friday morning. T h u r s d a y afternoon will b e free. F o r sightseeing besides Seattle, Vancouver, BC, is within easy driving distance, and Victoria, B C , and t h e San J u a n islands can b e reached b y ferry service. A mixer will be held a t the Leopold Hotel in Bellingham Tuesday evening (8:00 t o 11:00 p j n . ) . A Symposium Banquet ($5) will b e held in the same hotel Wednesday evening. On T h u r s day there will b e a salmon barbecue supper ($2) a t Lakewood, a forested lakeside t r a c t owned b y t h e College. Transportation will b e arranged for these events. Special events for guests of symposium· participants include a shopping and sightseeing t r i p t o Vancouver, B C , on Wednesday. Symposium participants will b e housed a t M a t h e s Hall. A charge of $32 includes half of a twin-bedded room, a buffet supper Tuesday evening, breakfast and lunch on Wednesday through Friday, and the salmon

barbecue supper on Thursday. T h e above package with a single room is $39.50. Meals alone including the barbecue are $17. A list of motels and hotels is available on request. Those planning t o fly should schedule their arrivals at the Seattle-Tacoma airport. Symposium planners will provide ground transportation directly t o Bellingham and will be contacting participants on receipt of registration forms. E a r l y information is necessary t o plan for transportation which will incur extra charges. T h e r e is also bus

View of Mathes Hall a t Western Washington State College where summer symposium participants will be housed

ANALYTICAL CHEMISTRY. VOL. 4 4 , NO. 4 , APRIL 1972

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News & Views service (schedules available) between the airport and Seattle and between Seattle and Bellingham. Persons interested in attending this symposium should fill out the registration form and return it with a $15 registration deposit before May 19, 1972. Late registration will, of course, be accepted, but early registration will ease arrangements for accommodations and transportation. The program chairman of this symposium is Merle A. Evenson, Dept. of Medicine, University of Wisconsin, 1300 University Ave., Madison, WI 53706. Local arrangements chairman is Donald M. King, Dept. of Chemistry, Western Washington State College, Bellingham, WA 98225.

Registration Form, 25th Annual Summer Symposium June 13 t o 16, 1972 Division of Analytical Chemistry and Analytical Chemistry Western Washington State College Bellingham, WA 98225 Date_

Name (please print)

Dr. Mr. Mrs. Miss

Mailing Address:, Professional Affiliation:

1972 Analytical Summer Symposium PROGRAM Wednesday, June 14 Wednesday Morning J. C. White, ORNL, Oak Ridge, TN, Presiding 9:00 D. M. King, Western Washington State College, Bellingham, WA 9:15 Alex Kaplan, University of Washington, Seattle, WA 10:45 George Z. Williams, M.D., George Z. Williams Research Institute of Laboratory Medicine, San Francisco, CA Wednesday Afternoon Fred Baumann, Varian Associates, Walnut Creek, CA, Presiding 2:00 Irving Shain, University of Wisconsin, Madison, WI 3:00 William Campbell, NIH, National Institute of General Medical Science, Bethesda, MD Thursday, June 15 Thursday Morning H. A. Laitinen, University of Illinois, Urbana, IL, Presiding 9:00 George Morrison, Cornell University, Ithaca, NY 10:30 Joseph Jordan, Pennsylvania State University, University Park, PA Thursday Evening R. S. Melville, Research Grants Branch, NIGMS, National Institutes of Health, Bethesda, MD, Presiding 7:00 Gary Zimmerman, Seattle University, Seattle, WA 8:30 Paul Strandjord, M.D., University of Washington, Seattle, WA Friday, June 16 Friday Morning Paul Van Dreal, Hycel, Inc., Presiding 9:00 James Riordan, Harvard Medical School, Boston, MA 10:30 Ian Carlson, University of Wisconsin, Madison, WI 52 A ·

Registration Fee: $15 Campus housing and food service include: half of a twin-bedded room, Tuesday through Thursday nights; buffet supper Tuesday (5:00 to 7:00 p.m.); breakfast and lunch, Wednesday through Friday; barbecue supper Thursday. Total charge per person, $32 (single accommodations at $39.50). Meals alone (including barbecue supper) can be purchased for $17. Separate tickets for the barbecue can be purchased for $4.50. Please check appropriate items: I would like to share a double room with . I will share a double room with someone you assign. J prefer single room accommodations. I would like accommodations for myself and the following members of my family (give names and, if children, their ages).

. I will arrange for my own housing accommodations. me a list of the local hotels and motels.

Please send

_l expect to attend the mixer Tuesday evening, June 13 (8:00 to 11:00 p.m.). Please indicate the number if more than one. J expect to attend the Symposium Banquet, Wednesday evening, June 14. ($5 per person, please indicate number if more than one). Please make day, June 15.

^additional reservations for the barbecue supper, Thurs-

_reservations for the ladies' sightseeing and shopping Please make trip to Vancouver, BC, on Wednesday, June 14 ($2.50 per person). NonU.S. citizens should bring appropriate border crossing documents. I plan to travel by plane_ I plan to arrive on June, on June at

auto_ (approximate time) and depart at .(approximate time).

.1 would like transportation from the Seattle-Tacoma Airport to Bellingham (please indicate the number if more than one). This form should be returned before May 19, 1972, together with a $15 registration deposit to: Dr. Donald M. King, Department of Chemistry, Western Washington State College, Bellingham, WA 98225. Make your check payable to: Western Washington State College.

ANALYTICAL CHEMISTRY, VOL. 44, NO. 4, APRIL 1972

News & Views

Heroin Detection by FRAT A modified electron spin resonance spectrometer forms the basis of the FRAT spin immunoassay system used by Syva for detection of drugs. The system is used by the Army to screen returning soldiers from Vietnam to determine their freedom from heroin addiction. It is also used in preemployment drug screening programs by companies and in methadone maintenance clinics. More recently the instrument and analytical technique form the basis of a community methadone detoxification clinic in suburban NewJersey. Dr. Raymond Banta heads the Valley Center in Ridgewood, NJ, where in addition to dealing with heroin addiction, he has programs concerned with youthful venereal disease and pregnancy. In the methadone detoxification program, addicts are identified by first name and date of birth only. The detoxification occurs over a period of nine days and consists of administering smaller and smaller doses of methadone along with counseling and other aids. The advantage of the FRAT method in the clinic is the rapid determination (30 sec) of morphine, a metabolite of heroin, in urine. The FRAT instrument is easily operated, and in the Valley Center two nurses perform the tests. They were readily taught to prepare samples, operate the instrument, and report results. The use of this spin immunoassay method for testing for opiates in urine and its place in the treatment of heroin addiction will be reported by R. Leute and E. Ullman, of Syva, and Avram Goldstein, M.D., Professor of Pharmacology, Stanford University Medical School, in papers in JAMA and Nature. Dr. Goldstein is a consultant for Syva, originators of FRAT. Syva is a joint venture of subsidiaries of Syntex and Varian. They have developed the spin label and other chemicals necessary to the FRAT system. They are now field testing reagents for use in testing amphetamines and barbituates. The basic instrument is a modified Varian E-4 electron spin resonance spectrometer. When the urine samples, containing among other things, nitroxide spin labels, are placed in a homogeneous magnetic field, microwave transitions may be induced between the various electronic energy states. Esr signals are then observed, the intensity of which is proportional to the concentration of nitroxide radicals in solutions. If no opiates are present, the equilibrium constant of the complex chemical reaction within the sample is shifted so as to reduce the number of free radicals in solution; that 54 A ·

Scheduled Courses in Analytical Techniques Information is given in the following order: date, name of course, location of course, professional person(s) in charge of course, and/or sponsoring organizations, cost if known, and Contact (numbers in parentheses refer to addresses and telephone numbers given at the bottom of the list of scheduled courses). Apr. 5 to 7—Liquid Chromatography. Framingham, MA. Contact: William A. Dark, Waters Assoc, Inc., 61 Fountain St., Framingham, MA 01701. 617-8792000 Apr. 6—Color Measurement Workshop. Toronto, Canada. Hunterlab. Contact: Margaret Burns, Hunter Assoc. Laboratory, Inc., 9529 Lee Highway, Fairfax, VA 22030. 703-591-5310 Apr. 10 to 14—Two Separate Courses: Gas Chromatography; Electronics for Chemists. Philadelphia, PA. Sadtler Research. $275 each. Contact (1) Apr. 10 to 14—Photomicrography. London, England. McCrone Research. £55. Contact (2) Apr. 11 to 13—Analysis of Specks and Deposits (related to pulp and paper). Appleton, Wl. C. V. Piper. Contact: T. A. Howells, The Institute of Paper Chemistry, Appleton, Wl. 414-734-9251 Apr. 17 to 21—Microscopy and Photomicrography in Medical and Biological Laboratories. London, England. £55. McCrone Research. Contact (2) Apr. 19 to 21—Liquid Chromatography. Houston, TX, Area. Varian Aerograph. Contact (3) Apr. 21 to 22—Modern Liquid Chromatography. Charleston, WV. L. R. Snyder, J. J. Kirkland. ACS. $90, text $15. Contact (4) Apr. 24 to 25—Thermoanalysis. $150. Philadelphia, PA. Sadtler Research. Contact (1) Apr. 24 to 25—Introductory and Advanced Workshops in Thin-Layer Chromatography. Durham, NC. Camag. $35/person/day or $60/twodays. Contact (5) Apr. 24 to 28—Hot-Stage Microscopy. Chicago, IL. McCrone Research. $275. Contact (2) Apr. 24 to 28—Techniques of Infrared Spectrophotometry. Philadelphia, PA. Sadtler Research. $275. Contact (1) Apr. 26 to 28—Gas Chromatography. Montreal, QUE, Canada, Area. Contact: Martin Hughes, Varian Assoc, of Canada, Ltd., 6358 Viscount Rd., Malton, ONT, Canada Apr. 26 to 28—Gas Chromatography. Montreal, QUE, Area. Varian. Contact (6) Apr. 27 to 28—Introductory and Advanced Workshops in Thin-Layer Chromatography. College Park, Md. Camag. $35/person/day or $60/two days. Contact (5) May 6 to 7—Modern Liquid Chromatography. Pittsburgh, PA. L. R. Snyder, J. J. Kirkland. ACS. $90, text $15. Contact (4) May 10 to 12—Liquid Chromatography. Cincinnati, OH, Area. Contact: Chane Graziano, Varian Aerograph, Executive Park Suite 125, Louisville, KY 40207 May 15 to 16—Introductory and Advanced Workshops in Thin-Layer Chromatography. Rochester, NY. Camag. $35/person/day or $60/two days. Contact (5) May 15 to 19—Microscopy in the Crime Laboratory. Chicago, IL. McCrone Research. $275. Contact (2) May 17 to 19—Gas Chromatography. Houston, TX, Area. Varian Aerograph. Contact (3) May 18 to 19—Introductory and Advanced Workshops in Thin-Layer Chromatography. Cleveland, OH. Camag. $35/person/day or $60/two days. Contact (5) May 18 to 20—Industrial Experiments: Factorial Designs. Red Carpet Inn, Charlotte, NC. J. Stuart Hunter, John D. Hromi. Charlotte Section and the Chemical Div. of the American Society for Quality Control. $190. Contact: Wylene Wylie, 1051 Ridge Rd., Rock Hill, SC 29730 May 22 to 26—Color and the Behavior of Colorants. Charlotte, NC. $250. Contact: James G. Davidson, Kollmorgen Technical Center, Dixie River Road, Rt. 4, Box 408-B, Charlotte, NC 28210. 704-394-3131 May 29 to June 2—Applied Statistics for Engineers, Scientists, and Technologists. University of Texas. F. Brons. Contact: Engineering Institutes, P.O. Box K, University of Texas at Austin, Austin, TX 78712

is, the nitroxide moieties remain bound to their parent molecules. When morphine is present (metabolite of heroin), it reacts with the parent molecules in a manner which reverses the equilibrium reaction and increases the concentration of free nitroxide spin labels. The instrument operator then observes a dramatic increase in esr intensity. Barbiturates, amphetamines, and methadone do not interfere with the opiate test.

ANALYTICAL CHEMISTRY, VOL. 44, NO. 4, APRIL 1972

The possibility of developing spin labels that would permit the determination of other compounds including steroids, hormones, etc., is an interesting speculation. It seems likely that spin immunoassay methods will have increased importance in biological and medical areas as research progresses. Other methods currently in use for the analysis of opiates and other drugs of abuse in blood and urine require extraction followed by thin-layer chro-

News & Views June 2 to 3—Maintaining and Trouble-Shooting Chromatographic Systems. Chicago, IL. J. Q. Walker, M. T. Jackson. ACS. $90. Contact (4) June 5 to 6—Introductory and Advanced Workshops in Thin-Layer Chromatography. Dallas, TX. Camag. $35/person/day or $60/two days. Contact (5) June 5 to 8—Introduction to Modern Liquid Chromatography. Philadelphia, PA. John Cassels, Karl Bombaugh. Sadtler Research. $250. Contact (1) June 5 to 16—Modern X-ray Spectrometry. State University of New York at Albany. Contact: Henry Chessin, State University of New York at Albany, Dept. of Physics, 1400 Washington Ave., Albany, NY 12203 June 6 to 24—Digital Computers in Chemical Instrumentation. Purdue University. Contact: S. P. Perone, Chemistry Dept., Purdue University, Lafayette, IN 47907 June 7 to 9—Liquid Chromatography. Atlanta, GA, Area. Varian. Contact: Tom Campbell, Varian Aerograph, 180 Allen Road, N.W., Atlanta, GA 30328 June 8 to 9—Introductory and Advanced Workshops in Thin-Layer Chromatography. Houston, TX. Camag. $35/person/day or $60/two days. Contact (5) June 11 to 17—Chromatographic Techniques in Forensic Analysis. Georgetown University. V. Horak, S. Kumar, R. de Levie. Contact (7) June 12 to 14—Interpretation of Uv Spectra. Philadelphia, PA. A. R. Gennaro. Sadtler Research. $200. Contact (1) June 12 to 16—Thin-Layer Chromatography. Philadelphia, PA. F. M. Rabel. Sadtler Research. $275. Contact (1) June 12 to 16—Color and the Behavior of Colorants. Attleboro, MA. $250. Contact: Ruth M. Johnston, Color Systems Div., 67 Mechanic St., Attleboro, MA 02703. 617-222-3880 June 14 to 16—Gas Chromatography. Springfield, NJ, Area. Varian. Contact: Ed Gelb, Varian Aerograph, # 2 5 , Route 22, Springfield, NJ 07081 June 19 to 23—Industrial Use of the Polarizing Microscope. Chicago, IL. McCrone Research. $275. Contact (2) June 19 to 23—X-Ray Powder Diffractometry. State University of New York at Albany. Contact: Henry Chessin, State University of New York at Albany, Dept. of Physics, 1400 Washington Ave., Albany, NY 12203 June 21 to 23—Liquid Chromatography. Malton, ONT, Canada. Varian. Contact (6) July 10 to 22—Fluorescence and Phosphorescence in Forensic Analysis. Georgetown University. C. S. Furfine, R. H. Young. Contact (7) July 17 to 21—Forensic Document Microscopy. Georgetown University. J. M. English. Contact (7) July 24 to 28—Forensic Analysis of Writing Inks. Georgetown University. E. P. Cofield, Jr. (Scripto, Inc.); R. W. McKinney (W. R. Grace & Co.). Contact (7) July 24 to 28—Forensic Microscopy of Human and Animal Hairs and Fibers. Georgetown University. Marie Jones (Bristol-Myers Co.). Contact (7) July 24 to Aug. 4—Forensic Optical Microscopy. Georgetown University. Mary L. Willard (Pennsylvania State University). Contact (7) July 31 to Aug. 4—Forensic Analysis of Ethyl Alcohol. Georgetown University. Dr. H. C. Freimuth (Office of the Chief Medical Examiner, Baltimore, MD). Contact (7) July 31 to Aug. 4—Forensic Microscopy of Synthetic and Cellulosic Fibers. Georgetown University. R. Scott (Du Pont). Contact (7) Aug. 7 to 18—Forensic Microscopic Analysis of Inorganic Ions. Georgetown University. Elizabeth Anne Whitman (Naval Ordance Station, Indian Head, MD). Contact (7) (1) Sadtler Educational Div., Sadtler Research Laboratories, Inc., 3316 Spring Garden St., Philadelphia, PA 19104. 214-382-7800 (2) Mrs. Miriam L. Fallert, McCrone Research Institute, 451 E. 31st St., Chicago, IL 60616. 312-842-7105 (3) Don Brasseaux, Varian Aerograph, Suite 180. 3939 Hillcroft Ave., Houston, TX 77027 (4) Education Dept., American Chemical Society, 1155 Sixteenth St., N.W., Washington, DC 20036. Late registrants, please call 202-737-3337, ext. 258 (5) Camag, Inc., 2855 S. 163rd St., New Berlin, Wl 53151. 414-786-9550 (6) Martin Hughes, Varian Assoc, of Canada, Ltd., 6358 Viscount Rd., Malton, ONT, Canada (7) Joseph M. English, Forensic Sciences Center, 9 Reiss Science Bldg., Georgetown University, Washington, DC 20007

matography and gas chromatography or spcctrofluorescence. The FRAT method, although requiring a $26,000 instrument, is sensitive and specific and rapid and can be justified if the sample load is sufficiently large. Persons can be readily trained to perform the test, and an extraction step is not required. The capillary sample tube holds a minimal amount of urine. The optimal amount of urine used is 50 pi. Further sensitivity can be achieved, of course,

by also extracting the drugs initially, but the advantages of speed and simplicity would then be sacrificed. * The use of methadone in both detoxification and in methadone maintenance programs is subject to a great deal of controversy. The maintenance program represents a short cut technological answer to a serious social problem as described by Dr. Etzioni and Mr. Remp in Science, 175 (4017), 31 (1972).

Call for Papers Pacific Conference on Chemistry and Spectroscopy and Annual Meeting of Optical Society of America Jack Tar Hotel, San Francisco, CA October 16 to 20, 1972 Included in the subject-areas of this meeting are atomic and emission spectroscopy; analytical chemistry; clinical chemistry; environmental chemistry; mass spectroscopy; multichannel analyzers, computers and interfaces ; sampling, vibrational spectroscopy; X-ray spectroscopy; and optics. Submit abstracts of 200 words before May 1, 1972 to Albert Castro, ACS, Chemistry Dept., San Jose State College, San Jose, CA 95114, or Victor Buhrke, SAS, Buhrke Co., P.O. Box 2243, Menlo Park, CA 94025. For information on the Optical Society program, write to Sumner P. Davis, OSA, Physics Dept., University of California, Berkeley, CA 94720. 4th International Conference on Atomic Spectroscopy Toronto, ONT, Canada October 29 to November 2, 1972 Papers, both theoretical and applied, in the fields of atomic absorption, emission, and fluorescence and spectroscopy are invited. Program information is available from C. L. Chakrabarti, Dept. of Chemistry, Carleton University, Ottawa K1A 5B6, ONT, Canada; other information is available from M. K. Ward, National Research Council of Canada, Ottawa K1A OR6, ONT, Canada Recent Advances in the Analytical Chemistry of Pollutants Dalhousie University, Halifax, Canada August 23 to 25, 1972

NS,

Papers are invited on any topic concerned with the subject area. Abstracts of not more than 200 words should be submitted to Louis Ramaley, Dept. of Chemistry, Dalhousie University, Halifax, NS, Canada, by April 15, 1972. 11th National Meeting of Society for Applied Spectroscopy Statler-Hilton, Dallas, TX September 10 to 15, 1972 Included in the program will be all phases of applied spectroscopy plus special symposia on Mossbauer, X-ray, far infrared, and emission spectroscopy; spectrochemical applications in the determination of geological origin, numerical methods for the resolution of spectral data; ultratrace analysis; atomic spectroscopy in flames, furnaces, and plasma ; low-temperature spectroscopy ;

ANALYTICAL CHEMISTRY, VOL. 44, NO. 4, APRIL 1972 ·

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News & Views

gas chromatography-mass spectros­ copy. For further information contact Phil Kane, Texas Instruments, Inc., P.O. Box S936, M/S 147, Dallas, TX 75222. 1972 Eastern Analytical Symposium Chalfonte-Haddon Hall, Atlantic City,

NJ October 31 to November 2, 1972 Contributed papers with emphasis in the areas of general spectroscopy, gen­ eral chromatography, and new com­ mercial instruments with applications are desired. Submit papers to Η. Η. Richtol, Chemistry Dept., Rensselaer Polytechnic Institute, Troy, NY 12181. Enzymology in Clinical Medicine

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ANALYTICAL CHEMISTRY, VOL. 44, NO. 4, APRIL 1972

Three institutions are planning pro­ grams in enzymology this spring and summer. They are the University of Minnesota, Mount Sinai Hospital Medical Center, and Massachusetts In­ stitute of Technology. A course, "Enzymology in the Prac­ tice of Laboratory Medicine," will be given May 10 to 12, 1972, at the Mayo Memorial Auditorium. This course is being sponsored by the Department of Laboratory Medicine and the Office of Postgraduate Medical Education at the University of Minnesota. Details are available from Dr. James M. Schless, Director of the Office of Postgraduate Medical Education, Box 193, Mayo Memorial Bldg., Minneapolis, MN 55455. An International Seminar and Work­ shop on Enzymology will be held May 22 to 24, 1972, at Mount Sinai Hospital Medical Center. The program is spon­ sored by the University of Health Sci­ ences/The Chicago Medical School and Mount Sinai Hospital Medical Center, Chicago, IL, and is primarily designed for clinical laboratory directors and supervisors. The faculty includes H. U. Bergmeyer, Germany; D. Moss, England; G. N. Bowers and R. B. McComb, Hartford, CT; J. James, B. A. Johnson, and R. Schaffer, Knoxville, TN, and NBS, Washington, DC; C. F. Fasee, W. Copeland, and R. E. Vanderlinde, Albany, NY; G. P. Hicks, Mad­ ison, WI; A. Karmen, New York; A. F. Krieg, Hershey, PA; R. N. Rand, Phila­ delphia, PA; and staff members. The total program includes lectures, demon­ strations, and discussions. For more information and registration forms, write to Norbert W. Tietz, Professor and Director of Clinical Chemistry, Mount Sinai Hospital Medical Center, Chicago, IL 60608. Massachusetts Institute of Technol­ ogy Summer School Program in En­ zymes and Their Use in Analysis and

News & Views

Clinical Diagnosis will take place at MIT, July 10 through 14, 1972. The objective of this program is to develop the participants' abilities to use enzymes as analytical reagents and to measure enzyme activities in biological materials. A comprehensive theoretical back­ ground will be given, and an awareness of the powerful means of medical diag­ nosis provided by measuring enzyme activities in blood samples and biopsies will be stressed. Further information is available by writing to the Director of the Summer Session, Room E19-356, Massachusetts Institute of Technology, Cambridge, MA 02139.

Coming Events The following meetings are newly listed in Analytical Chemistry. For meetings through December 1972 previously scheduled, see the March 1972 issue beginning page 46 A. May 1—Symposium on High-Performance Liquid Chromatography. Play­ boy Club Hotel at Great Gorge, Mc­ Afee, NJ. Contact: Ed Gelb, Varian Aerograph, #25, Route 22, Spring­ field, NJ 07081 May 3 to 5—18th ISA Analysis Instru­ mentation Symposium. William Penn Hotel, Pittsburgh, PA. Contact: R. P. Trauterman, Allegheny Ludlum Steel Co., River Road, Brackenridge, PA 15014 May 9 to 11—Tenth Annual Vacuum Technology Seminar. Palo Alto, CA. Contact: Varian Vacuum Seminar Registrar, 611 Hansen Way, Palo Alto, CA 94303 June 2 to 8—Environmental Tech­ niques, Man, Air, and Water. Expo­ sition Center, Parc de Versailles, Paris, France. Contact: Techno­ expo, 8, rue de l a Michodiere, 75 Paris 2e, France June 5 to 9—31st Congress of Groupe­ ment pour l'Avancement des Méthodes Physiques d'Analyse (GAMS) with Société Chimique de France. Paris, France. Contact: Secretariat de GAMS, 10, rue du Delta, 75 Paris 9e, France July 4 to 6—Biomedical Engineering Exhibition. Bloomsbury Centre, London. Includes equipment and instrumentation related to research and clinical medicine. Contact: Bevan Gilpin, Bloomsbury Centre, Coram St., Russell Square, London WC1, England. Tel: 01-437 5353 July 10 to 14—Third International Conference on Measurement of Air Quality. Johnson State College, Johnson, VT. ASTM Committee D-22. Contact: P. M. Giever, Rt. 8, Allison Park, PA 15101 July 24 to 28—31st ISA Research Conference on Instrumentation Science. Hobart & Wm. Smith College. Contact: J. Dimeff, NASA, Ames Research Center, Moffett Field, CA 94305 Aug. 23 to 25—Recent Advances in the Analytical Chemistry of Pollutants. Dalhousie University, NS. Contact:

CALENDAR OF EVENTS Apr. 3 to 7

International Congress ση Analytical Chemistry. Kyoto, Japan. Contact: T. Fujinaga, Faculty of Sciences, University of Kyoto, Kyoto, Japan. Page 46 A, Jan.

Apr. 9 to 14

163rd National American Chemical Society Meeting. Boston, MA. Includes Analytical Division Sessions. Contact: W. Wayne Meinke, National Bureau of Standards, Washington, DC 20034. Page 41 A, Mar.

Apr. 9 to 14

Federation of American Societies for Experimental Biology. At­ lantic City, NJ. Contact: Helena B. Lemp, FASEB, 9650 Rockville Pike, Bethesda, MD 20014

Apr. 10 to 14

Applications of Nuclear Activation Techniques in the Life Sciences. Ljubljana, Yugoslavia. Contact: International Atomic Energy Agency, Karntnerring 11-13, A-1011, Vienna, Austria. Page 33 A, Dec.

Apr. 11 to 14

Optical Society of America National Meeting. New York, NY. Contact: J. W. Quinn, Optical Society of America, 2100 Penn­ sylvania Ave., N.W., Washington, DC 20037. 202-293-1420

Apr. 2 1

Meeting on Diffraction Gratings. Imperial College, London SW7. Contact: The Institute of Physics, 47 Belgrave Square, London SW1X 8QX, England

Apr. 24 to 25

Second Annual Symposium on Mass Spectrometry. Du Pont Country Club, Wilmington, DE. Contact: T. R. Garrett, Du Pont Instruments, 1500 S. Shamrock Ave., Monrovia, CA. 213-357-2111

Apr. 24 to 26

7th ISA Maintenance Management Instrumentation Symposium. William Penn Hotel, Pittsburgh, PA. Contact: R. P. Trauterman, Allegheny Ludlum St. Co., River Rd., Brackenridge, PA 15014

Apr. 24 to 26

Seventh Annual Meeting Association for the Advancement of Medi­ cal Instrumentation. Las Vegas, NV. Contact: AAMI, 9650 Rockville Pike, Bethesda, MD 20014. Page 40 A, June

Apr. 25 to 28

Fifth Annual Scanning Electron Microscope Symposium and Work­ shops. Chicago, IL. Contact: Om Johari, HT Research In­ stitute, 10 West 35th St., Chicago, IL 60616. 312-225-9630. Page 49 A, Nov.

Apr. 25 to 28

International Exhibition for Biochemical and Instrumental Analy­ sis. Munich, Germany. Contact: Biochemische Analytik 72, Tagungsleitung, Dr. H. Schievelbein, D-8000 Munich 15, Nussbaumstrasses 20, Germany

Apr. 28 to 29

Association of Clinical Scientists. Holiday Inn, Elkhart, IN. Contact: A. H. Free, Ames Co. Div., Miles Laboratories, Inc., Elkhart, IN 46514

Apr. 3 0 to May 2

American Society for Clinical Investigation. Chalfonte-Haddon Hall, Atlantic City, NJ. Contact: S. K. Herliz, 850 Third Ave., New York, NY 10022. 212-421-6900

Apr. 3 0 to May 4

18th Annual Meeting of the Institute of Environmental Sciences. American Hotel, New York City. Contact: Institute of En­ vironmental Sciences, 940 E. Northwest Highway, Mount Pros­ pect, IL 60056. 312-255-1561. Page 64 A, Oct.

Apr. 3 0 to May 4

13th Experimental Nuclear Magnetic Resonance Conference. Asilomar Conf. Grounds, Pacific Grove, CA. Contact: E. Lustig, F.D.A. BF-145, 200 C St., S.W., Washington, DC 20204

Louis Ramaley, Dept. of Chemistry, Dalhousie University, Halifax, NS, Canada. Page 55 A, Apr. Sept. 3 to 16—NATO Advanced Study Institute on Nuclear Magnetic Resonance Spectroscopy of Elements Other Than Hydrogen. Pisa, Italy. Organizing Committee: T. Axenrod (CCNY); E. D. Becker (NIH); G. Berti

(University of Pisa); A Mannschreck (University of Regensburg). Contact: G. Berti, Institute of Organic Chemistry, University of Pisa, Via Bonanno 6, Pisa, Italy 56100 Sept. 11 to 13—5th International Symposium on Quantitative "Flat-Bed" Chromatography. Includes theoretical treatment; influence of sorbent;

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VARIAN'S NEW $1Q700 60-MHz NMR SYSTEM GIVES YOU HIGH PERFORMANCE, EXCELLENT VERSATILITY...

News & Views biological and enzymatic methods; combination with gc, Ic, and electrophoresis; use of radioisotopes. Carlsbad, Czechoslovakia. Contact: K. Macek, 3rd Medical Dept., Charles University, Prague 2, U nemocnice 1, Czechoslovakia Oct. 25 to 31—4th International Chemistry Exhibition and MAC '72. Milan, Italy. Contact: FAST, Pie R. Morandi 2, Milano, Italy 20121 Oct. 29 to Nov. 2—4th International Conference on Atomic Spectroscopy. Toronto, ONT, Canada. Contact: C. L. Chakrabarti, Carleton University, Ottawa K1A 5B6, ONT, Canada. Page 55 A, Apr.

For Your Information Varian Aerograph Chromatography Data Systems now publishes a quarterly, the Catalyst, designed for all customers interested in laboratory automation. The quarterly will contain information on new installations, applications, technical discussion, new developments, personalities, and software tape releases. Interested persons should write to Jim Rhinehart, Varian Aerograph, Chromatography Data Systems, 2700 Mitchell Drive, Walnut Creek, CA 94598

,AND A CHOICE Varian Anaspect's new EM-360 has a guaranteed resolution of 0.6 Hz and a guaranteed sensitivity of 15:1 using 5-mm sample tubes. A variety of operating parameters makes the system easy to operate with a maximum of performance flexibility. And it's priced lower than any other 60-MHz NMR system suitable for both teaching and research. Look at these outstanding operating advantages. Continuously variable rf power allows full utilization of the six available sweep times. Six scale expansions let you make the best choice for your application.There's an exclusive end-of-sweep control; a standby lock; a large, flexible XY recorder; a built-in integrator; an accessory oscilloscope (optional). And the instrument's design lets you add on other accessory modules of your choice as they become available. The EM-360 evolved from Anaspect's approach to economical manufacturing plus Varian's leadership in NMR. It's one of a unified line of products from Varian Anaspect. .. specialist in quality instruments designed to give you more data per dollar. So, if you're in the market for a low-priced NMR system with high performance, talk to the NMR specialist who gives you a choice. The versatile, new EM-360, or the even lower-priced 30-MHz EM-300. With 60-day delivery on 60-MHz systems. For bulletin, spectra, and locations where you can see an operating EM-360, contact your local Varian NMR representative. Or write Varian Anaspect, 611 Hansen Way, Palo Alto, California 94303.

varian anaspect See the EM-360 at the Boston ACS Meeting in April. CIRCLE 1 8 7 O N READER SERVICE CARD

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ANALYTICAL CHEMISTRY, VOL. 4 4 , NO. 4 , A P R I L 1972

Krueger Enterprises, Inc., 24 Blackstone St., Cambridge, MA 02139, 617876-3691, has formed a new operating division, the Environmental Research Division. Research is already underway in several areas including studies of the distribution of heavy metals in the environment and the uses of stable isotopes for environmental tracing. Also under consideration are sampling devices for pollution monitoring. Science Essentials Co., a division of Beckman Instruments, Inc., will distribute Sartorius filter membranes, filter holders, and electrophoresis strips in the U.S. under an exclusive longterm agreement with Sartorius-Membranfilter GmbH, of Gottingen, W. Germanv. Science Essentials, P.O. Box 6100, Anaheim, CA 92608, 717-6368781, was established last year by Beckman to distribute lab equipment and supplies for hospitals, clinics, etc. A monthly subscription service for the analysis of chemical molecules in the pharmaceutical field has been announced by Mme. Irene Duval-Valachs of CEDOPÎ (Centre d'Etudes Documentaires de Propriété Industrielle), a Paris company specializing in patent searches. The new service is called Pharmsearch. Further information is available by writing to Mme. Duval-Valachs, CEDOPI, 21, rue de Leningrad, 75Paris 8, France. Tel: 292 25 14

News & Views The Avco Systems Division of Avco, 201 Lowell St., Wilmington, Mass. 01887, 617-657-4423, offers a test service including measurement standards, chemical analyses, nondestructive testing, environmental testing, mass-spectrometric testing, and other services related to quality control. Billings & Gussman, Inc., 1254 Main St., Waltham, Mass. 02154, 617-8919380, announces a "Hi-Vol Filter Analytical Service." All standard filter analyses will be offered.

Fast and accurate

nanosecond fluorescence lifetime spectra using the single-photon counting technique A digital approach Single-photon counting, a highly sensitive technique which actually samples individual quanta of light, is generally acknowledged to be the best method of measuring very low light levels. Now Ortec has applied this technique to the field of nanosecond fluorescence spectroscopy. The Ortec Model 9200 Nanosecond Fluorescence Spectrometer uses a short duration optical light pulse to excite the sample and measures the decaying fluorescence intensity as a function of time over several decades. Our system offers sensitivity and accuracy increased by orders of magnitude compared to existing analytical techniques. This new system is already producing outstanding results in studies of chemical reaction rates, molecular structure, and molecular conformation changes. Improved data reduction A multichannel analyzer records each detected fluorescence photon against a time base for immediate CRT display or Teletype printout of the spectrum. Data is manipulated and stored in a digital,

computer-compatible mode. A computer interface can thus be incorporated to facilitate reduction of complex data. The 9200 system will measure both single and multiple decay components. Multiple components are clearly represented on the spectrum and easily read. (The spectrum above shows the straight line response of a sample having a single lifetime.) Sensitivity is better than 1 ppb quinine sulfate in sulfuric acid. Linearity is typically better than 1 % . System components The exact system configuration will depend on the user's particular requirements, but the basic system consists of a nanosecond light puiser, sample chamber including photomultiplier, multichannel analyzer, and associated electronics. The entire system is designed around NIM-standard modules for enhanced flexibility, reliability, and ease of servicing. Data sheet on request If you'd like more information on the Ortec Model 9200 Nanosecond Fluorescence Spectrometer, we'd be happy to send you a data sheet that tells all about it. Just write or call Ortec Incorporated, 110 Midland Road, Oak Ridge, Tenn. 37830. Phone: (615) 482-4411. In Europe: Ortec Ltd., Dallow Road, Luton, Bedfordshire. Phone: LUton 27557. Ortec GmbH, 8 Munchen 13, Frankfurter Ring 8 1 , West Germany. Phone: (0811) 359-1001.

ORTEC EG&G COMPANY

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Beckman Instruments, Inc., 2500 Harbor Blvd., Fullerton, Calif. 92634, 714-871-4848, has announced a costper-test rental plan for its clinical glucose analyzers. Contract prices range from $1.02 per test at the rate of 150 tests per month to 17tfper test at the rate of 2000 tests per month. A new organization, Technical Specialists International, California Federal Bldg., Suite 225, 608 Silver Spur Rd., Palos Verdes Peninsula, CA 90274, provides a central marketplace for obtaining technical talent and providing support services and group benefits to individual consultants and small technical firms. Varian has consolidated six operations into the Varian Instrument Division, a major analytical instrument facility. The new division consists of the former Varian Analytical Instrument Division, Palo Alto; Varian Aerograph Division, Walnut Creek; Cary Instruments, Monrovia ; Varian Anaspect, Palo Alto ; and the U.S. marketing activities for Varian MAT (Germany) and Varian Techtron (Australia). The Varian Instrument Division has headquarters at 611 Hansen Way, Palo Alto, CA 94303, and Robert Wehrli is General Manager. The Institute for Scientific Information (ISI), 325 Chestnut St., Philadelphia, PA 19106, 215-923-3300, offers a new information-alerting service consisting of weekly bibliographies of the journal literature published on nearly 100 scientific subjects with high research priorities. ASCATOPICS will monitor the complete output of the 2500 most important scientific and technical journals for areas in environmental science, medicine, biology, and chemistry, with emphasis on pollutants, pesticides, food additives, and drugs. Cost varies, but most subjects can be covered for $95/ year for 52 bibliographies.

News & Views

BioSciences Information Service of Biological Abstracts (BIOSIS), 2100 Arch St, Philadelphia, PA 19103, 215568-4010, has introduced Bioresearch Today, a series of monthly journals covering specific subjects of investiga­ tion. Each issue will contain abstracts appearing in Biological Abstracts rele­ vant to the researcher's subject area. This service is designed to be an inex­ pensive reference tool to ''zero in" on subject specialties. Sadtler Research Laboratories, 3316 Spring Garden S t , Philadelphia, PA 19104, 215-382-7800, offers a new audiovisual program describing the use of its spectral reference collections and indices. The 22-miu program is avail­ able either as a. set of 30 35-mm color slides or in 35-mm filmstrip format. Wilks Scientific Corp., South Norwalk, CT 06856, has revamped its company periodical. Infrared Neivs, and promises more frequent publication. The A7ews is designed to keep recipients up-todate on applications on infrared, with emphasis on the company's MIBAN analvzers. Interactive programs for X-ray fluores­ cence analysis based on the fundamental parameters method described in Anal. Cliem., 40 (7), 1080 (1968) are avail­ able. Written in KRONOS 2.0 FOR­ TRAN for time-shared CDC 6400 com­ puters, the programs require only mini­ mal input from the analyst, since the fundamental parameters may be stored permanently and accessed automati­ cally. Information is available from the X-ray Optics Branch, Code 6680, Naval Research Laboratory, Washing­ ton. DC 20390

KNOW WHAT'S ON YOUR SURFACES? IF Y O U D O N ' T , it could be costing you. T O F I N D O U T , Auger Electron Spectroscopy is the tool to use. It'll tell you the composition of the outer few layers of atoms quickly and accurately. It'll detect all elements except hydrogen and helium with a sensitivity of about 0.1 atomic percent. It's fast enough to monitor dynamic changes via oscilloscope dis­ play. It can provide accurate in-depth composition profiles when used in conjunction with simultaneous sputter-etching. And . . . a typical system costs less than $50,000. The two Auger spectra below were obtained from two gold plated LEAD frames with distinctly different bonding characteristics. The specimen with poor bonding properties shows distinct thallium contamination while the other does not. Other impuri­ ties are common to both specimens. Measurement of the indepth distribution of thallium showed that it was localized within 20 A of the surface. Investigation of this problem using any other technique . . . even x-ray analysis . . . would have been next to impossible. With Auger Electron Spectroscopy it was simple and straight-forward.

MG Scientific Gases in Kearny, N J , has changed its name to MG Scientific, a division of MG Technical Products,

Inc. The name change reflects the company's interest in other product lines including analytical instruments and high-purity chemicals, in addition to rare and specialty gases and gas mix­ tures. A product catalog is available by writing to MG Scientific at 1100 Ha rrison Ave, Kearny, NJ 07029 Data General Corp., Southboro, ΛΤΑ, maker of the Nova line of minicom­ puters, lias appointed manufacturers' representatives in Switzerland and Mexico. Sen Electronique, 31 Avenue Ernest Pictet, Geneva. Switzerland, and Mexitek, S.A., Eugenia 408. Deptos, ]y5, Mexico 12, D.F.. have been named.

If you'd like to know what's on your surfaces, you should be checking into Auger Electron Spectroscopy; and for information about Auger spectroscopy, call the people who wrote the book...

Call PHI PHYSICAL ELECTRONICS INDUSTRIES, INC. 7317 South Washington Avenue Edina, Minnesota 55435

(612) 941-5540 Tlx: 29-0407

CIRCLE 145 ON READER SERVICE CARD ANALYTICAL CHEMISTRY, VOL. 4 4 , NO. 4 , A P R I L 1972

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