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The long road to relief. Linda G. Griffith was 11 years old when the pain started. A searing sensation, as if a massive stone... SCIENCE CONCENTRATES ...
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EDITOR-IN-CHIEF: M.G. FINN Georgia Institute of Technology School of Chemistry and Biochemistry Atlanta, Georgia 30332 USA (404) 385-0906 [email protected]

ASSOCIATE EDITORS Larry Truesdale NovaBay Pharmaceuticals, Inc. [email protected]

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Jason Hattrick- Simpers University of South Carolina [email protected]

FOUNDING EDITOR Anthony W. Czarnik University of Nevada, Reno

MANAGING EDITOR Ranjini Prithviraj [email protected]

EDITORIAL ADVISORY BOARD Fernando Albericio University of Barcelona

Steven Firestine Wayne State University

Yulin Lam National University of Singapore

Radislav Potyrailo GE Global Research

Jeffrey Aubé UNC Chapel Hill

Justin P. Gallivan Emory University

Craig W. Lindsley Vanderbilt University Medical Center

Floris P. J. T. Rutjes Radboud University Nijmegen

Xu Bai Jilin University Mark Bradley University of Edinburgh Stefan Bräse Karlsruhe Institute of Technology Gerardo Byk Bar Ilan University Gerbrand Ceder UC Berkeley Young-Tae Chang National University Singapore Andrew D. Ellington The University of Texas at Austin Jonathan Ellman Yale University Michael Fasolka National Institute of Standards and Technology (NIST)

Samuel Gerritz Bristol-Myers Squibb Yong-Dae Gong Dongguk University John Gregoire Caltech R. Kiplin Guy St. Jude Children’s Research Hospital Paul R. Hanson University of Kansas

Alfred Ludwig Ruhr-Universität Bochum Wilhelm Maier University of Saarland Andreas Marzinzik Novartis Institutes for BioMedical Research Morten Meldal SPOCC Center

Ulrich S. Schubert Friedrich-Schiller University, Jena Kay Severin Swiss Federal Institute of Technology Lausanne Ahmad Shaabani Shahid Beheshti University Ichiro Takeuchi University of Maryland Shu-Jiang Tu Xuzhou Normal University

Craig Hawker University of California

Delia Milliron University of Texas at Austin

Thomas Kodadek The Scripps Research Institute

Michael G. Organ York University

Hideomi Koinuma National Institute for Materials Science (NIMS)

Seung Bum Park Seoul National University

Victor Krchnák University of Notre Dame

Patrick Pasau UCB

Zhen Yang Peking University

Kit Lam University of California, Davis

John A. Porco, Jr. Boston University

Wei Zhang University of Massachusetts Boston

Yashiro Uozumi Institute for Molecular Science Seong Ihl Woo KAIST Jie Wu Fudan University