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ACS NEWS & SPECIAL FEATURES Linda Raber, Assistant Managing Editor Susan J. Ainsworth (Senior Editor), Corinne A. Marasco (Senior Editor), Linda Wang (Associate Editor) EDITING & PRODUCTION Robin M. Giroux, Managing Editor for Production Alicia J. Chambers (Assistant Editor), Arlene GoldbergGist (Senior Editor), Faith Hayden (Assistant Editor), Kenneth J. Moore (Assistant Editor), Tonia E. Moore (Assistant Editor), Kimberly R. Twambly (Associate Editor), Lauren K. Wolf (Assistant Editor) C&EN ONLINE Rachel Sheremeta Pepling, Editor Tchad K. Blair (Visual Designer), Luis A. Carrillo (Production Manager), Ty A. Finocchiaro (Web Assistant), William B. Shepherd (Manager, Online Recruitment), Noah Shussett (Associate Web Content Manager) PRODUCTION & IMAGING Renee L. Zerby, Lead Digital Production Specialist Krystal E. King (Lead Digital Production Associate) SALES & MARKETING Elise Swinehart, Assistant Director Elaine Facciolli Jarrett (Marketing Manager) ADVISORY BOARD: Magid Abou-Gharbia, Kim Baldridge, David N. Beratan, Jim Birnie, Lukas Braunschweiler, Joseph C. Breunig, Gary Calabrese, David Clary, Rita R. Colwell, E. J. Corey, Marijn E. Dekkers, Daryl W. Ditz, Michael P. Doyle, Arthur B. Ellis, Robin L. Garrell, James R. Heath, Rebecca Hoye, Nancy B. Jackson, Harry Kroto, Roger LaForce, Aslam Malik, Andrew D. Maynard, Eli Pearce, Marquita M. Qualls, Sara J. Risch, Alan Shaw, Rakesh (Ricky) S. Sikand, Thomas R. Tritton, Pratibha Varma-Nelson, Paul A. Wender, George Whitesides, Frank Wicks Published by the AMERICAN CHEMICAL SOCIETY Madeleine Jacobs, Executive Director & CEO Brian Crawford, President, Publications Division EDITORIAL BOARD: John N. Russell Jr. (Chair); ACS Board of Directors Chair: Judith L. Benham; ACS President: Bruce E. Bursten; Ned D. Heindel, Madeleine M. Joullié, Leah Solla, Peter J. Stang Copyright 2008, American Chemical Society Canadian GST Reg. No. R127571347 Volume 86, Number 48
FROM THE EDITOR
Life As We Don’t Know It IF YOU THINK OF LIFE on Earth as a mag-
nificent incarnation of natural technology, then life has the classic double-edged character of all powerful technologies. This technology has produced a wondrous diversity of beings displaying a gorgeous marriage of form and function on hierarchical levels that span the range from cells to rain forests and beyond. Yet it also has created pathogens that indifferently kill millions of people each year, ecological disasters that wipe out species, and intelligent beings that deliberately perpetrate catastrophes on similar scales. On Nov. 14, I attended a “discussion” at the Woodrow Wilson International Center for Scholars in Washington, D.C., titled “Synthetic Biology: Coming Up Fast!” It made me wonder whether the scientific community might be approaching another Promethean moment, like the one associated with the emergence of nuclear technology last century and that ever since has committed humanity to shepherding nuclear technology’s promise while containing its perils. The discussants were Denise Caruso, executive director of the not-for-profit Hybrid Vigor Institute, a consultancy “dedicated to interdisciplinary and collaborative problem solving,” and Rick Weiss, formerly a science writer with the Washington Post and now a senior fellow with the D.C.-based think tank Center for American Progress (CAP). The two chatted comfortably in a faux on-stage living room. CAP cosponsored the event with the Wilson Center’s Project on Emerging Nanotechnologies. The driver of their discussion is a cadre of scientists and entrepreneurs who run companies with names like Synthetic Genomics and who aim to create, exploit, and perhaps unleash new-tothe-world biological constructs. Like synthetic chemists who make artificial molecules, synthetic biologists synthesize biological units—such as genes, chromosomes, and entire genomes—in order to replicate, alter, build upon, or otherwise create synthetic biological entities. By taking biology in new directions, which some have expressed in sound-bites as “genetic engineering on steroids,” synthetic biologists contend that they might solve some of the world’s most vexing health, environmental, and energy conundrums.
And they just might. Think of inserting a synthetic chromosome into a bacterium so that it single-handedly converts cellulose into fuel or decontaminates a Superfund site and you will begin to think like a wellintentioned synthetic biologist. Deputy Assistant Managing Editor Stu Borman and Associate Editor Britt Erickson covered some of the field’s promise and risks in the past two issues (C&EN, Nov. 17, page 62, Nov. 24, page 28). What concerns me is that the lofty ambitions of synthetic biologists could come at costs that we quite literally cannot imagine. After all, said Caruso, who has examined synthetic biology extensively, “biology is a tremendously complex system, which we don’t know so much about, and we are releasing it into a complex environment where we don’t have any idea what the long-term consequences might be.” On top of that, she continued, is the likelihood that the all-too-human foibles of greed, stupidity, malice, and buffoonery will render synthetic biology’s cost-benefit balance even harder to predict. “The technologies and products for creating synthetic components are already affordable and widely available to virtually anyone with access to the Internet, a credit card, and a shipping address,” Caruso has written. In time, we may have to contend with a new class of scoundrels—synbio hackers. The cinematic magnitude of the possibilities would be merely entertaining if they weren’t on this side of the fiction line. A few years ago, scientists at the State University of New York, Stony Brook, chemically synthesized a working poliovirus (Science 2002, 297, 1016). To drill in the reality that they had made the viral particle, they referred to it as C332,652H492,388N98,245O131,196P7,501S2,340. This is not a call for moratorium, and Caruso did not lobby for one either. Synthetic biology is coming, but we should address it with our eyes wide open—it will come with its own Promethean burden for humanity to bear.
Managing editor
Views expressed on this page are those of the author and not necessarily those of ACS. W W W.CE N - O N L IN E .O RG
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