Direct racemic separation - Now you can directly resolve racemic amines, acids and fa''» "' ' " "" many other compounds without any preceding prepara tions of derivatives. Use the new EnantioPac HPLC cartridge column from LKB. It outdates every other known separation technique with a completely novel and patent ed approach. EnantioPac is based on the immobilized plasma protein a, -acid glycopro tein, which shows high enantioselectivity for a wide range of pharmaceuticals and other chiral substances. Lets you screen for optical purity very fast, very simply and very reliably. Substance Atropine Bromdiphenhydramine Brompheniramine Bupivacaine Butorphanol Carbinoxamine Chlorpheniramine Clidinium Cocaine Cyclopentolate
Substances separated with EnantioPac 1.53 1.64 Dimethindene Diperodone 1.47 1.17 Disopyramide 2.70 1.50 Doxylamine 1.37 1.41 Ephedrine 1.83 1.99 Ephedrine, pseudo-1.34 1.33 Homatropine 1.63 2.26 LabetalolA 2.10 1.21 LabetalolB 1.36 1.46 Mepensolate. 1.32 3.86 Mepivicaine 1.25
Methadone Methorphan Methylatropine Methylhomatropine Methylphenidate Metoprolol Nadolol A Nadolol Β Oxyphencyclimine Oxprenolol
1.59 Phenmetrazine 2.54 Phenoxybenzamine 1.27 Promethazine 4.2 Pronethalol 1.70 Propoxyphene 1.64 Propranolol 3.98 Terbutaline 3.03 Tocainide 1.42 Tridihexethyl 1.25 THmeprazine
1.57 1.37 1.25 1.26 2.3 1.13 1.22 1.44 1.64 1.11
This list is published by the kind permission of Goran Schill, Thomas D. Doyle and Irving W. Wainer, Division of Drug Chemistry, Food and Drug Administration, Washington DC. Λ^
Applications and references You'll find these in our latest brochure. Together with detailed tech nical information about this revolutionary new column. Get in touch with LKB. We'll send you all the facts. Fast!
LKB
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BROMMA LKB-Produkter AB, Box 305, S-16126 Bromma, Sweden. Tel. +46(8)98 0040, telex 10492 Antwerp (03) 218 93 35 Athens-Middle East +30 (1) 894 73 96 • Copenhagen (01) 29 50 44 · Hongkong (852) 5-555555 London (01) 657 88 22 · Lucerne (041) 57 44 57 · Madras (044) 45 28 74 - Moscow (095) 256-9002 • Munich (089) 85 830 Paris (06) 928 65 07 • Rome (06) 39 90 33 · Stockholm (08) 98 00 40 Tokyo (03) 293-5141 Turku (021) 678 111 Vienna +43 (222) 92 16 07 Washington (301) 963 3200 - Zoetermeer (079) 3192 01 Over 60 qualified representatives throughout the world.
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CIRCLE 126 ON READER SERVICE CARD ANALYTICAL CHEMISTRY, VOL. 58, NO. 3, MARCH 1986 • 439 A
