Local Anesthetics. VII. Monoalkylamino-4-alkoxy-3-aminobenzoates

4.320

ir.

FKEIFELDER,

M. B.MOOKE, AI. K.

[ CONTRIBUTIOV FROM

I~ERNSTEN ASD ( > . I H!>:i I: V I

11.19

9,Ii'J 10.17 10 39 !Li!l) 1001 10 0 3

Kitrogen, ' C Calcd. Found 7.81 7.60 7.28 7.2: 0.7fi 6,73 ii70 tiOti ( i 89 (8.70 i.32 7.81

L.40

li,i(i

ti.fi2

33 7.81

7.C7

t).00 7 25

7.29

ti

7.88 F.53 .?.HI,

yield. Reaction with ethylene ;Ilso prepared by method B in 7 .ilso prepared by method C in 63.5% yield. --C(CH3!2Reaction with ethylene oxide carried out at 125" for 24 hours. oxide carried out a t 90-100' for 5 hours. CH2C(CHa'13. f Reaction irith ethylene oxide carried out at 150" for 28 hours. 0 Cyclohexyl. Ik

TABLE Y

n PSZTl,AI.KYI,.4MIS(jAI,K~'l, -~LKOXYNITRODENZO.4TE HYDKOCHLORIDES, RO--